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What makes cannabis medical?

Discussion in 'Medical Discussion' started by C No Ego, Aug 3, 2017.

  1. chris 71

    chris 71 Well-Known Member

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    C No Ego those are some awesome links thanks
    has me really inspired to get the cannabinoids back into my system . especially after reading some of the stuff about cbd and even 1to1 ratios thc to cbd . i was doing so much better before i stopped using cannabis . and some of this reading has me convinced more then ever that it really was so helpful to me . both mentally and physically when dealing with my graves and mental health issues .
     
  2. CarolKing

    CarolKing Singer of songs and a vapor connoisseur

    Cannabis & Digestion
    It's no secret – experiencing “the munchies” is one of the most obvious cannabis clichés. Despite the silly connotation, studies suggest that the endocannabinoid system actually helps modulate appetite. This is especially interesting for the treatment of eating disorders. In fact, a study published in the International Journal of Eating Disorders suggests that cannabinoids may prove effective in treating anorexia.

    Cannabis is also famously used to reduce the feelings of nausea but studies suggest it could have a number of digestive benefits as well. Medical marijuana could play a role in a number of digestion-related health conditions including:

    Medical Marijuana For Pain Management
    [​IMG]Chronic Pain is one of the most common ailments for which doctors prescribe medical marijuana and a recent survey published in The Spine Journal found that 1 out of 5 patients at a Colorado spine center were using cannabis to manage their pain. Of those, nearly 90% said it greatly or moderately relieved their pain.

    The spine clinic study was merely a survey, which means more research will be necessary on the potential role of cannabis in treating back pain. With that said, plenty of people will tell you it helps manage pain and science is beginning to back their claims. Studies suggest medical marijuana could offer relief for various types of pain, including the following:

     
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  3. Ohmie

    Ohmie Govrnmnt fund adult circumcision & frenuloplasty!

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    I remember posting about this in another thread. I mentioned Marijuanas self defense mechanisms which I'd heard included attracting carnivores to it's vicinity w it's aroma/munchies to scare away herbivores. LOL, Another feminine trait, right?
    Marijuana apparently coexisted with dinosaurs. I think the article was from IFLS(IFuckingLoveScience). I never did find it so I ould post the link, but it would makes sense to me and would be pretty crucial to the plants effects overall.
    This molecule eerily resembles my Vapor Koozie.Lol
    [​IMG][​IMG]
     
    Last edited: Aug 27, 2017
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  4. C No Ego

    C No Ego Well-Known Member

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    Glad to help at least one person to come to their Own Conclusions... Our modern underground breeding of cannabis has led to out of balance breeding IMO leaving CBD in the dust... Diets too- when we get the correct (PUFAS) poly unsaturated fatty acids, in correct ratios we signal more cb channels naturally...that means we can exercise more and have that lipid oxidatant neutralizing buffer to signal cellular efficiency in our ECS... the cell wall is lipid for a reason, we are carbon based life forms ( lipid fat organizers LOL) ...As a side note- I'm just looking into Shungite water too as a carbon/hydrogen antioxidant boost...
    it is looking like the hydrogen and oxygenating sequencing of the decarboxylated cannabioids ( Tri-cylclic terpene) make them hyper active... that oxygenated hyper activity in the phyto-cannabinoid when introduced to our receptors super charges our receptor capacity to even signal retrograde through signalling! @EverythingsHazy = that would be the bad IMO- that hyper activity of the compound, Though cb channeling cascade is initialized @ the neuron if I'm not mistaken then outer feelers ( sphongolipids) detect available arachidonic acid to then bio-synthesize the cannabinoid to signal through with... this cascade initiated internal of the cell to then rely on diet based PUFAS to create through structures... I call phyto-cannabinoids micro dietary structures, small,small food LOL

    so, in terms of safety (LD50) it goes back to amounts introduced= dose.... We have billions of cells with Unknown receptor Amounts On Each Cell that are activated through dietary lipophylic compounds! Without structural integrity ( cannabinoids) to maintain those structure activated through channels the cell goes Dormant and eventually dies from oxidation realted stress.... :(

    Too, I know this is petri dish science but it leads us to show the mechanism of action ( bio-chemical pathways) of the cannabinoids....
    In a solution of cancerous cells and healthy cells mixed together while exogenous cannabinoids were introduced to the dish the receptor channels, both cb1 receptors for feeding ions and cd2 for modulating protein were activated and accumulated on the cancerous cells only while leaving healthy cells untouched! in the test they called it apoptosis...

    So I'm reading your post and setting down the focus vape- My vape clicked the Pain Link LOL... vape made me click IT! lol

    Thanks
    @Ohmie LOL Man Awesome--- The Mica in the soil determines what fragrances cannabis can formulate... the mica (metallic oxide) becomes terpenes!


    In one respect "The Cannabis" needed people or upright being to Shit their DNA all around... they make smells to Attract humanoid species and other Divine carriers of the Shit
     
    Last edited by a moderator: Aug 27, 2017
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  5. Ohmie

    Ohmie Govrnmnt fund adult circumcision & frenuloplasty!

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    :shit::shit::tinfoil::shit::shit:
    ......

    I guess if most other species didn't exist there'd be one side of the planet covered in some ginormous gathering of a single breed of plant and the other sides covered in some other kinds
     
    Last edited: Aug 27, 2017
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  6. Little Bill

    Little Bill Oldest stoner on FC

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    :love::love::love:

    Nothin better than sittin, self-medicatin, and readin the brilliant posts of yall.

    ...as Bill said; depends on what the meaning of the word "is" is. :myday:
     
  7. Ohmie

    Ohmie Govrnmnt fund adult circumcision & frenuloplasty!

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    Ok, now I see.. I missed this part on the first read.. "Lucky Poo"..maybe why the leaf looks like bird feet
     
    Last edited: Aug 27, 2017
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  8. gangababa

    gangababa Well-Known Member

    Messages:
    420
    Location:
    center of the jagat
    "estar" or no "ser"?
    "IS-NESS" is but what is IS?

    or did I take that one toke too far?
     
    Last edited: Aug 27, 2017
  9. Ohmie

    Ohmie Govrnmnt fund adult circumcision & frenuloplasty!

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    My psychiatrist put me on Saphris attempting to wean me from Marijuana with sweet dreams/deeper sleep and hefty meals. The first night I did dream that I was a shrunken Harry Potter in like that candy shop in the stories; which I attributed to how my psychiatrist looked in his lab coat or whatever and how I'd like to feel with the munchies sometimes, but i wanted a therapeutic hobby like weed rather than a one dose or die type deal which is mental disorder in itself.
     
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  10. C No Ego

    C No Ego Well-Known Member

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    I have no idea what that medication is but if your doctor does not condone Marihuana "the devils lettuce " then i wonder why... My psychiatrist became a naturopth! he said he could not prescribe another drug or he himself would go crazy!
     
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  11. Ohmie

    Ohmie Govrnmnt fund adult circumcision & frenuloplasty!

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    It felt like Xanax to me but it's intended as a sleeping aid. Its a lasenge or however you spell the tablets that dissolve on your tongue. On my initial visit he was like hinting that he would prescribe Mary if the state would allow it but by the second or third session he was babbling about how he didn't see the use in weed, I'm sure simply for the purpose of prescribing me the saphris
    [​IMG][​IMG][​IMG]
     
    Last edited: Aug 28, 2017
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  12. C No Ego

    C No Ego Well-Known Member

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    Ok, the more physical Labor I do the More cannabis is Medical IMO LOL...

    Here below is the difference in medical and recreational cannabis. Note, there are huge differences between medical and recreational and I can see why everyone is so confused!

    Recreational =

    Get home from work- sit back, relax and light the vape up and inhale vapor= cannabinoid relief

    .......................................


    Medical=

    Get home from work- sit back, relax and light the vape up and inhale vapor= cannabinoid relief


    See the difference? I mean they are worlds apart right and this warrants so much confusion the world over! Look there- that guy is absorbing plant cannabinoids! is it rec or med?... only that person knows because it's his business.. if there is any confusion try it for yourself to determine med or rec or maybe even a little of both mixed in together...Anyway, my rant is over and back to more medical discussion...


    After asking what exactly makes cannabis medical and looking at what we term medical I've come to the conclusion that decarboxylated, ( carbon neutral) heated cannabis serves more medical type effects in the short term approach...
    the main reason here IMO is because biological activity increases as more of the active fundamental structure is exposed from a compound molecule IE phyto-cannabinoid... Hypophylic intracellular permeability (signal transduction) comes to mind..

    eating raw cannabis presents a carboxylic form ( carbon active) of those same compound molecules but you cannot term them active in that carboxylic state because the fundamental bioactive structure is encapsulated in amino acid- raw amino acids. the Raw consumption approach would be a more long term medical strategy as in food and enzymes...
    I was recently reading some info explaining that our bodies cb receptors recognize thc-a / cbd-a (raw cannabis) as more of an endocannabinoid that could be beneficial to us?
    I've also seen info that shows that because of the cannabis molecules' encapsulated carboxylic acid in the raw form it does not have a neuronal effect @ the active receptor site as the size is to big to make it through the blood brain barrier...

    The verdict is still out on Raw verses heated cannabis as which is most beneficial... I see it as for short term relief use heated and for long term future harm prevention raw...
     
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  13. C No Ego

    C No Ego Well-Known Member

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    Last edited: Sep 3, 2017
  14. EverythingsHazy

    EverythingsHazy Well-Known Member

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    Thanks for the tag.

    In regards to a less commonly discussed, but great potential medical benefit of Cannabis, I made a new thread about Cannabis and traumatic brain injury. Hopefully, more light will be shed on the issue, in the coming years, but for now, whoever has any info specific to that topic, feel free to share it over in that thread.
     
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  15. C No Ego

    C No Ego Well-Known Member

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    Wow man., I'll check it out thank you.. I am fascinated in the neuro-genesis aspect of the added supplemental cannabinoids and cellular recognition/ sparked regeneration/ pre-designed re-purposed signalling agents (FCC) etc... but have visualized how it works with inner science only LOTL
     
  16. C No Ego

    C No Ego Well-Known Member

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    916
    Here are a few more great articles... one is dealing with cancer and the endocannabinoid system and the other dealing with anxiety disorders


    Cancer-

    https://www.intechopen.com/books/na...rspective-of-cannabinoids-in-cancer-treatment

    pdf of same article

    https://cdn.intechopen.com/pdfs-wm/54967.pdf

    anxiety treatment

    Cannabidiol as a Potential Treatment for Anxiety Disorders

    https://link.springer.com/article/10.1007/s13311-015-0387-1


    I would like to add too the importance of Beta carophyllene ( black pepper etc..) as a dietary cannabinoid that acts as a reverse agonist mediator @ cb1 and cb2 receptors to stop anxiety and stall metabolic signalling of the more active metabolites thc and cbd... it is called FAAH

    http://www.bionity.com/en/encyclopedia/FAAH.html
     
  17. MinnBobber

    MinnBobber Well-Known Member

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    3,398
    ........................................
    Can you please expand as I didn't see the connection between black pepper and FAAH, thanks.
    And---does FAAH knock down/shorten the effects of cannabis as , "(FAAH) it hydrolyzes bioactive amides including the endocannabinoid anandamide"...
     
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  18. C No Ego

    C No Ego Well-Known Member

    Messages:
    916

    I'll try and find the more pertinent beta caryophyllene info and get back to you. to explain it some- beta caryophyllene is an inverse agonist that acts on cb1 and cb2 but not directly through cb receptor channels... the inverse agonist part of the equation makes it act like an antagonist (cbd) that prolongs immediate through signalling..
    FAAH actually pro-longs receptor active effects mediating signalling too...
    I'll link this here tooas it is the best thread @ GC IMO

    https://forum.grasscity.com/threads/cannabis-black-pepper.1282798/

    @MinnBobber

    I think this part explains it well... just a random find really
    "Whereas, in other types of receptors that have been studied, ligands bind externally to the membrane, the ligands of GPCRs typically bind within the transmembrane domain."
    From http://www.bionity.com/en/encyclopedia/G_protein-coupled_receptor.html
     
    Last edited: Sep 10, 2017
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  19. MinnBobber

    MinnBobber Well-Known Member

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    3,398
    ............................................................................................
    I find the science of "bio-availability" of compounds fascinating.

    Due to several health issues, and my physical therapist recommending natural anti-inflammatory use of pineapple, papaya, and tumeric with black pepper, I've done some digging and it is amazing.
    I was familiar with black peppers' use as a "cannabis overdose" medicine to calm the anxiety via its beta-caryophyllene but pepper is not a "one trick pony" :)

    5% of black pepper is piperine which makes the tumeric/curcumin less water soluble in the liver so it is more difficult for the body to excrete it (pee it out). Experiments have shown that small amounts of black pepper can make tumeric 2000% more bio-available.
    Furthermore, taking some fat with tumeric allows it to bypass the liver and enter the bloodstream directly via the lymphatic system--- I don't understand that mechanism yet, if anyone can help explain the lymphatic process, please do!!
    So I'm doing "tumeric firecrackers", tumeric + small amount of black pepper, buried in some heated peanut butter to make a "paste without the tumeric taste" ;) Black pepper and fat to help boost the tumeric/curcumin absorption

    Black pepper and cannabis?? I had thought pepper was sort of a "downer" to a cannabis dose BUT does it really extend the dose like it does for tumeric? Does it hinder the body from getting rid of the cannabis goodies???
    Does "stalling the metabolic signalling of THC and CBD" mean the effect is not as big/high??... BUT it lasts longer, like the long lasting effects of cannabis edibles??

    Time for my firecracker :)
     
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  20. C No Ego

    C No Ego Well-Known Member

    Messages:
    916

    molecular imprinting... We offer to the world an intent, plants are here to serve if you ask and will re-present your intent in a more grounded fashion connected to the earth with stabilized evolution.. 120 active molecular phyto-compounds have been recognized in cannabis... each of those 120 cannabinoids represent active biological information that imprint structuring upon active environmental sensitive cb receptors that only signal when in- structured to do so..lol

    Another explanation of beta caryophyllene..quoted...random find from to many articles- lol
    "The potential presence of allosteric binding sites on CB1 receptors and the design of selective agents targeting these sites would be especially advantageous, because full agonists evoke robust internalization of cannabinoid receptors (Jin et al., 1999), which lead to in vivo tolerance (Tappe-Theodor et al., 2007), and renders pharmacological exploitation difficult."
    From https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273654/#S6title
    specifically- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273654/#S4title


    Using those volatile terpenes like beta caryophyllene, amounts matter but to bio-augment other heavier molecular structures like thc/cbd use about @ a ten percent solution ratio to your dose... this is especially accurate with topical solutions..

    If you have an opportunity add a drop of clean rose oil to your solution to purify it... here are some of the cleanest I've found http://alchemistoils.com/

    edit too
    The cannabinoid 2 receptor agonist β-caryophyllene modulates the inflammatory reaction induced by Mycobacterium bovis BCG by inhibiting neutrophil migration
    https://link.springer.com/article/10.1007/s00011-016-0969-3


    Also, Quote from article below..
    "The terpene β-caryophyllene is found in a number of commonly available plants, including black pepper, cinnamon, clove, and other spices. It selectively binds to the CB2 receptor at nanomolar concentrations and acts as a full agonist. β-Caryophyllene and cannabidiol occur abundantly in Cannabis sativa. So this plant species produces at least two entirely different chemical substances able to target CB2 receptors differentially. While studies on the pharmacokinetics of β-caryophyllene are still on-going, it is already clear that this terpene is readily bioavailable. Unlike many polyphenolic natural products, it is not metabolized immediately but shows a Tmax >1 h after one single oral administration."
    from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820295/#__sec8title

    @MinnBobber


    too...
    http://themedicalbiochemistrypage.org/eicosanoids.php

    quote from link above to explain FAAH- I'm finding it everywhere!

    "The principal eicosanoids of biological significance to humans are a group of molecules derived from the 20:4 (20 carbons: 4 sites of unsaturation) fatty acid, arachidonic acid. Additional biologically significant eicosanoids are derived from dihomo-γ-linolenic acid (DGLA) which is produced in the reaction pathway leading to arachidonic acid from the essential fatty acid, linoleic acid (see Figure below). Other important eicosanoids are derived from the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) which are derived from the essential fatty acid, α-linolenic acid (ALA), or obtained in the diet. The major source of arachidonic acid is through its release from membrane phospholipids. Within cell membranes, arachidonic acid resides predominantly at the C–2 position of phospholipids (primarily phosphatidylinositol-4,5-bisphosphate, PIP2) and is released from there upon the activation of the lipid hydrolase phospholipase A2, PLA2. Go to the Bioactive Lipids page for details on the various PLA2 enzymes.
     
    Last edited: Sep 10, 2017
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  21. C No Ego

    C No Ego Well-Known Member

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    her are some vids on the endocannabinoid system and bioactives... really interesting

    Click to play YouTube Video


    http://cannabisclinicians.org/minor-cannabinoids-and-cannabis-terpenoids/

    @MinnBobber -Bod Melamede could catapult you into new realms, please check his vids and info... Ethan Russo is more the sciency person but fascinating info on actives
     
  22. C No Ego

    C No Ego Well-Known Member

    Messages:
    916
    It seems that with the questionable Diets ( correct fats) we offer into our bodies to build and sustain stuff with ( internal body parts, what not)- Starting with multi diversified cannabinoid ratios (whole plant cannabis) and an efficient delivery system ( vaporizer) that presents as many of those bio-available bio-actives cleanly to adaptable cb receptors ( cannabinoid receptor) then Cannabis acts as a Super Vitamin just by helping to maintain intracellular calcium levels via cb1 receptor and protein regulation via cb2. plant based phyto-cannabinoids from cannabis are the correct type lipophilic compounds to activate or inactivate cb receptor capacity..

    We simply need more people willing to work with the plant ( all plants) and cannabis needs to be Not Regulated= way beyond legalization and decriminalization etc... Easy access and watch peoples' health improve and cannabinoid diversity in cannabis increase and knowledge too most importantly.
    Times of over criticizing cannabis harms via monkeys in smoke filled gas masks and dying from oxygen depletion as examples are over and new science / thought has emerged that do not serve to examine a smoked plant and it's toxic byproducts to determine what the plant is= cannabis sativa L or the smoke from cannabis sativa L .. look it up, that is how cannabis is regarded at the FDA DEA, etc... and still it's marijuana too - a freakin slang word made up to disassociate by association "hemp" and pull the wool over hemp farmers eyes... hemp farmers were the first victims of the petro chem take over and subsequent later drug war... one day their filed was hemp the next marijuana and a go to jail card... import Hash had a huge impact too on the start of this man against nature crap we are suffering from... sure nature is harsh but micro amounts ( cannabisnoids ) are therapeutic

    Ok, So a canna stem feel on the chair... I experienced my first harm from cannabis! it scratched my leg a little- a minor scratch... What did I do, I turned it into a medical act! I ate it = Yum, a burst of terpene flavor with a hint of bitterness which I love... Good Stuff
     
    Last edited: Sep 12, 2017
  23. C No Ego

    C No Ego Well-Known Member

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    916
    1975 called and want their cancer study re-examined....

    here is the actual Shaffer commission study from the Virginia medical school research looking to down play cannabis only to show it killing cancer!!! one of those how far ahead would we be now scenarios = reefer madness!

    Antineoplastic activity of cannabinoids.

    https://www.ncbi.nlm.nih.gov/pubmed?cmd=Retrieve&list_uids=1159836
     
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  24. CarolKing

    CarolKing Singer of songs and a vapor connoisseur

    A lot of these testing facilities, it sounds like they are using oral doses of the cannabis not inhaling it. That could make a difference how our bodies absorb the good stuff.

    Should we be ingesting cannabis in a different form? Using edibles with oil or RSO?
     
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  25. C No Ego

    C No Ego Well-Known Member

    Messages:
    916
    it is always a matter of bio-available absorption... otherwise we are just stuffing stuff in hoping it finds its way and does not get clogged in the process.. some of the test studies in the States had to rely on University of Mississippi to supply sub par cannabis and still had surprising results with that stuff.. but yeah, bio-availability is of most importance and should dictate anything we consume..
    oxygenating inactive compounds by adding high heat to make the compounds more bio-available does make bio-availability unpredictable somewhat, but then again delivery.. a good well made vape can really deliver what is in there imo but could be limited on impact of reach= how far deeply does the compound make into our biology, effects etc?
    When we pick up a vape and start a canna chemistry "Session" an alchemical bond occurs between man and plant, a bio-chemical reaction that targets regulatory cellular maintenance systems ECS... our cancer defense system in our bodies... proven that cb receptor knock out mice die from cancer and oxidation death quickly and do not eat anything... the opposite occurs when they over dosed the mice with cannabinoid sesame oil... They were living longer and defying cancer accumulation LOFL

    as to bio-availability- those same properties can be pre-heated to activate them into readily available bio-chemicals that are standardized into a solution to administer later @ correct dosing each time.. basically modern medicine etc...
    once people are allowed to test all of the bio-available compounds alchemicaly speaking in cannabis we will then know for sure all that the pl;ant has to offer..

    I've found that if used medicinally a spot treatment efficiently places the cannabinoids where their needed seems to be best and and overall increase of bio-actives that target our cb receptor capacity most efficiently... we have trillions of cb receptors and they are always active unless we're dead..


    adding cannabimimetics to Diet, Vaping, tincture, topical oil, paste, edibles,Patches, juicing, RSO, RSHO, nano enhanced liposomal delivery < looks interesting, and ways unknown yet to be found we salute you Cannabis :leaf:
     
    Last edited: Sep 17, 2017 at 3:06 PM
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