I apologize for not seeing this one til now! The stable up-temp method is wonderful, albeit time consuming. I do wonder if the hex-nail has automated this process yet though, if so, then it would be much easier to do more quickly
This is definitely the case if you continue to use escalating amounts of concentrates in the same way that gave one the initial large tolerance with flower.
As you say, tolerance can definitely sky-rocket either way. My starting material (flower) always ran out more quickly when I vaped flower only before I went to only vaping concentrates. I find that for medical scenarios like mine, if flower does not provide the required effects/longevity, it is even easier to overdo dosing than with concentrates which can provide the required effect with one small dose (flower also has the problem that some flowers from the same plant will have less resin than others which can make dosing more inconsistent). YMMV if you are using for different medical reasons or non-medical reasons of course.
I really can't relate to this, I've always gotten up and worked the next day as normal after a larger dosage the night before than I would usually have. This is profound because I have disabilities which would very often prevent somebody from EVER WORKING. Medical cannabis is the key to a productive, functional life for me.
I have no problems with staying mentally stable following the occasional larger intake of cannabis resin. Not to say that your experience was not exactly as you described, I of course take you at your word my friend
This is no doubt just individual variation, as you said, you suffered a brain injury and of course that can change what happens in your ECS in a very big way.
As above, endocannabinoids and endocannabinoid systems even in mammals long predate any records of plants containing phytocannabinoids. I remember reading this in an article by Ethan Russo not too long ago. If I recall the title, I'll share!
Some cannabis trivia: Many stoners think that the discovery of the endocannabinoid system is proof positive that we were MEANT to consume cannabis. This claim does not hold water when we consider the best available evidence showing that endocannabinoid systems long predate phytocannabinoids.