florduh
Well-Known Member
Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19
(2021, Aug 3)
Introduction: Recently, Dr Satoshi Omura, the Nobel co-laureate for the discovery of IVM, and colleagues conducted a comprehensive review of IVM clinical activity against COVID-19, concluding that the preponderance of the evidence demonstrated major reductions in mortality and morbidity [2]. Our review of that evidence, updated with consideration of several new studies, supports the same conclusion.
Conclusions: We believe that the evidence to date supports the worldwide extension of IVM treatments for COVID-19, complementary to immunizations. The indicated biological mechanism of IVM, competitive binding with SARS-CoV-2 spike protein, is likely non-epitope specific, as reviewed [8], possibly yielding full efficacy against emerging viral mutant strains. IVM has been safely used in 3.7 billion doses since 1987, well tolerated even at much greater than standard doses [34,35] and used without serious AEs in the three high-dose COVID-19 treatment studies noted above [34,36,37]. In the current international emergency of COVID-19, with mutant viral strains, vaccination refusals and potentially waning immunities over months presenting new challenges, IVM can be an effective component of the mix of therapeutics deployed against this pandemic.
The only study there recommending IVM came to that conclusion by squinting at statistics like excess deaths in areas with higher IVM usage. That's not how you determine if a specific drug works for a specific disease. Numerous other variables could explain these population wide differences in deaths. If IVM is an effective COVID treatment, a randomized control trial will demonstrate exactly that. Unfortunately...
Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19A Randomized Clinical Trial
"Among adults with mild COVID-19, a 5-day course of ivermectin, compared with placebo, did not significantly improve the time to resolution of symptoms. The findings do not support the use of ivermectin for treatment of mild COVID-19, although larger trials may be needed to understand the effects of ivermectin on other clinically relevant outcomes."
Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials
"In comparison to SOC or placebo, IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease. IVM did not have an effect on AEs or severe AEs. IVM is not a viable option to treat COVID-19 patients."The good news is, none of us need to worry about this. If someone gets a bad enough case of COVID that they maybe want to try ivermectin, they should be getting advice from their doctor. Just do what the doctor recommends. Exactly like you'd do with any other serious medical issue. Medical science isn't perfect but it's the best we have at this point.