Immune system vs. cannabis

[Sick Vape]

Pre vaporizing days I thought it was the cannabis that made me more miserable during a cold, but now I know it was the combustion. Also vitamin D/sunshine was lacking. Since in the medical program getting clean flower to vape daily, I have the sense of a constant plant residue in my upper respiratory tract that FEELS GOOD all the time. Balmy. I wonder if the anti viral/bacterial action is strong this way? I vape at low temps.

You could have a point.
limonene, 1,8-cineol, b-caryophyllene, b-pinene and others are known to be antiviral. THC and CBD also and probably other cannabinoids too.

@C No Ego I agree. Well, aside that CBD can have pretty immediate effects too. But I think I get what you are saying.

@ataxian &

 

[-dab8-]

Sorry I thought it could help. I'll keep my mouth shut.

Please don’t, all opinions and insights welcome here. I appreciate your input.

 

[ataxian]

You could have a point.
limonene, 1,8-cineol, b-caryophyllene, b-pinene and others are known to be antiviral. THC and CBD also and probably other cannabinoids too.

@C No Ego I agree. Well, aside that CBD can have pretty immediate effects too. But I think I get what you are saying.

@ataxian &

I know I sound like a GRUMPY OLD GRANDPA!
CANNABIS is safer than MILK?
Why is it fronded on?
HYPOCRISY!!

 

[hibeam]

Please don’t, all opinions and insights welcome here. I appreciate your input.

Haha, I think some people here do brag about microdosing...and it does deserve an award if one used to be a megadoser But ...

I know I sound like a GRUMPY OLD GRANDPA!
CANNABIS is safer than MILK?
Why is it fronded on?
HYPOCRISY!!

Milk surely does me way more harm! Cannabis may in fact protect one a bit from it?

 

[C No Ego]

4-give me 4 jumping on you mentally.

I have a strong conviction of the benefits of CANNABIS.

MICRO DOSE sounds like economics 2-me?
Maybe my opinion is different than yours?

yeah, it is economy based and health based and knowledge based somewhat... check out Dustin Sulak and his micro dose info on how initiating those enzymatic amides and epoxides ( FAAH / PPAR / TRPV1 / CYP450) via a micro dose of phytocannabinloid works. also, it activates the Arachadonic acid cascade , which is basically cannabinoid signalling via lipid metabolism and bio-active enzymes

 

[hibeam]

Hey @C No Ego, has this doc made the rounds here? Care and feeding of ECS:
https://www.beyondthc.com/wp-content/uploads/2013/03/McPartland-5-6.pdf

I just posted my breakfast on reddit:
https://www.reddit.com/r/FLMedicalTrees/comments/af8b8x/endocannabinoid_breakfast/

Yes! Our electro-chemical systems have supply demand issues.

 

[ataxian]

yeah, it is economy based and health based and knowledge based somewhat... check out Dustin Sulak and his micro dose info on how initiating those enzymatic amides and epoxides ( FAAH / PPAR / TRPV1 / CYP450) via a micro dose of phytocannabinloid works. also, it activates the Arachadonic acid cascade , which is basically cannabinoid signalling via lipid metabolism and bio-active enzymes

U will live forever like a celestial North KOREA!
I like CANNABIS.
Da more da better!

It’s my POV!

@hibeam I’m GF as well!

 

[Sick Vape]

Everything has its place.
Not everyone always can tolerate big doses. Not everyone always profits of microdosing (well maybe everyone would if the dose was apropriately chosen).
Microdosing works incredibly good for some things and people at certain times with certain strains.
Megadosing too.

I think there is no general rule of which one is better.
There is so much more happening than just big dose of cannabinoids or small dose of cannabinoids!

 

[analytika]

Everything has its place.
Not everyone always can tolerate big doses. Not everyone always profits of microdosing (well maybe everyone would if the dose was apropriately chosen).
Microdosing works incredibly good for some things and people at certain times with certain strains.
Megadosing too.

I think there is no general rule of which one is better.
There is so much more happening than just big dose of cannabinoids or small dose of cannabinoids!

It's what economists call a multivariate preference function. How do you balance your preference for: (I) how high, and (II) how often.

Microdosing isn't always about getting less high, it can be about not getting very high too often.

Microdosing isn't always about getting high less often, it can be about getting less high quite often.

Now, go optimize! It's about tolerance and preferences.

Side effects such as impact on the immune system don't necessarily follow the same toleramce rules.

If tolerance is less of a factor on immune system side effects, a microdoser may experience fewer immune system effects, for the same high.

 

[Madri-Gal]

I was poisoned badly in 2015 from contaminated romaine lettuce in a Caesar salad from a restaurant. Health Canada investigated and found the source to be one supplier of pre packaged lettuce. 80 people were poisoned over a two week period.

I was seriously ill for 28 months, hospitalised for over 20 weeks and underwent 3 operations. My Doctors said that I was lucky to have survived. My pancreas, liver and kidneys were damaged and there were problems with my sympathetic and parasympathetic nervous system. My digestive system was so compromised that I couldn't eat a lot of the time. I was not overweight at the onset and lost 50 lbs. At my worst I looked anorexic.

I used cannabis throughout my journey to recovery during the times I was at home. My liver recovered after 6 months and my kidney returned to normal function after 12 months. The pancreas required the three surgeries and is still limping along.

Cannabis helped ease my symtoms tremendously. It reduced my pain and helped me cut down on the amount of dilaudid I was taking. It wiped out the constant nausea and helped me relax and sleep. It helped me eat a bit and keep it down. In no way do I believe that my cannabis use was anything but beneficial to my recovery. I believe it not only eased my symptoms but also reduced systemic inflammation and helped speed my recovery. I vaped and took oral RSO daily.

Now I microdose throughout the day for pleasure and energy but I wouldn't hesitate to use it therapeutically again if the need arises.[/QUOTE
What a terrible thing to go through. I'm so glad you survived, and had cannabis to help.
Please don't take the brevity of this post to think I'm taking what you posted lightly. I'm a bit overwhelmed and distressed for you, and what you went through, and so very glad you are here.

 

[hibeam]

It's what economists call a multivariate preference function. How do you balance your preference for: (I) how high, and (II) how often.

Microdosing isn't always about getting less high, it can be about not getting that high very often.

Microdosing isn't always about getting high less often, it can be about getting less high.

Now, go optimize! It's all about tolerance.

Side effects like impact on the immune system don't necessarily follow the same toleramce rules. If tolerance is less of a factor on immune system side effects, a microdoser may experience fewer immune system effects, for the same high.

Could it simply be some users have such damaged eCB systems that the more cannabinoids the better to a much greater extent? While, others with mediocre to good eCB systems can accidentally throw theirs off by increased tolerance? I like the idea of protecting immunity by microdosing: some may really need to step this carefully.

 

[Sick Vape]

Yes. If it is about getting high, it's about tolerance, i think.
I only can build a tolerance for the high effect it seems. The effect on pain for example, especially severe pain stays the same.
I need the same amount even after a tolerance break. I just get very high then.
I cannot directly tell the impact on the immune system positive or negative, so it is impossible for me to detect tolerance buildup there.

I think we are at the beginning of trying to get to know the eCB system. It is huge and interferes everywhere. The more we research the more questions arise.
For the patients there is no time for waiting for the research. They need to be able try as many options as possible to see what helps them most.

 

[ataxian]

Yes. If it is about getting high, it's about tolerance, i think.
I only can build a tolerance for the high effect it seems. The effect on pain for example, especially severe pain stays the same.
I need the same amount even after a tolerance break. I just get very high then.
I cannot directly tell the impact on the immune system positive or negative, so it is impossible for me to detect tolerance buildup there.

I think we are at the beginning of trying to get to know the eCB system. It is huge and interferes everywhere. The more we research the more questions arise.
For the patients there is no time for waiting for the research. They need to be able try as many options as possible to see what helps them most.

I have late on set ATAXIA (SCA) if you can cure it my hats off 2 U!
MICRO is 4 some.

I like CANNABIS 4 managing my needs?
Sorry this not the right place 2-B!
Carry on my friends!

 

[C No Ego]

It's what economists call a multivariate preference function. How do you balance your preference for: (I) how high, and (II) how often.

Microdosing isn't always about getting less high, it can be about not getting very high too often.

Microdosing isn't always about getting high less often, it can be about getting less high quite often.

Now, go optimize! It's about tolerance and preferences.

Side effects such as impact on the immune system don't necessarily follow the same toleramce rules.

If tolerance is less of a factor on immune system side effects, a microdoser may experience fewer immune system effects, for the same high.

because the extracellular / exogenous second messenger phytocannabinoids act down stream they serve as down regulators/ modulators... if to much are present they then up regulate that ell function.
people mega dosing would be 360 degree regulating that function LOL ... Spiral / implosion regulation

@hibeam thanks for the link, I have gotten lost on that site a few times... to much suppressed info not enough time

 

[Sick Vape]

I have late on set ATAXIA (SCA) if you can cure it my hats off 2 U!
MICRO is 4 some.

I like CANNABIS 4 managing my needs?
Sorry this not the right place 2-B!
Carry on my friends!

I am no doctor, @ataxian. I wish I could cure you or help you. It seems you have found a way with cannabis to feel better. Thats good, no?
I am just a little dust on a pale blue dot.

@C No Ego that 360 degree regulating would only work on cyclic cell functions? (haha, officially marked as joke)

 

[Alex3oe]

I found that my reoccurring sicknesses (common cold, etc) throughout the year were severaly diminished when I gave up smoking cigarettes for vaping on an electronic cigarette.

smoking tobacco on a regular basis is not even very bad for the immune system, it makes it easier for bacteria or viruses to enter your system too

 

[ataxian]

I am no doctor, @ataxian. I wish I could cure you or help you. It seems you have found a way with cannabis to feel better. Thats good, no?
I am just a little dust on a pale blue dot.

@C No Ego that 360 degree regulating would only work on cyclic cell functions? (haha, officially marked as joke)

I am benefiting from CANNABIS.
I will not bother you fine members.
Like I said I don’t belong here!

 

[hibeam]

I am benefiting from CANNABIS.
I will not bother you fine members.
Like I said I don’t belong here!

Don't get too frustrated with us yet! The patients out there who neeeeeeeeeeeeeeeeeeeeeeeed
megadoses like you also need to raise their voices until they are heard. Our docs down here still blink at a gram per day recommendation, typically maxing it around 200mg THC. I go through around 40mg/40mg thc/cbd a day for my prob but my first doc would not let me have over 20mg.

 

[C No Ego]

Don't get too frustrated with us yet! The patients out there who neeeeeeeeeeeeeeeeeeeeeeeed
megadoses like you also need to raise their voices until they are heard. Our docs down here still blink at a gram per day recommendation, typically maxing it around 200mg THC. I go through around 40mg/40mg thc/cbd a day for my prob but my first doc would not let me have over 20mg.

RSO oil and cancer patients are using 1000 mg to 3000 mg daily activated 80 to 90% oil . if tolerance is of issue then a rectal suppository is used to offset tolerance to the compounds

 

[ataxian]

RSO oil and cancer patients are using 1000 mg to 3000 mg daily activated 80 to 90% oil . if tolerance is of issue then a rectal suppository is used to offset tolerance to the compounds

Where did you receive your PHD?

 

[C No Ego]

Where did you receive your PHD?

right here man @ FC

 

[Sick Vape]

RSO oil and cancer patients are using 1000 mg to 3000 mg daily activated 80 to 90% oil . if tolerance is of issue then a rectal suppository is used to offset tolerance to the compounds

I don't buy that suppositories don't get you high.
Has anybody really tried?


Edit: Sorry @C No Ego i am often questioning your posts lately. It has nothing to do with you. I like the posts

 

[looney2nz]

I don't buy that suppositories don't get you high.
Has anybody really tried?


Edit: Sorry @C No Ego i am often questioning your posts lately. It has nothing to do with you. I like the posts

I believe C No Ego is correct here.

this site/page is interesting: https://cannabiscure.info/cannabis-suppositories/

Originally conceived of and patented by the Israeli 'Father of Cannabis', with an accompanying paper in the Lancet in the '90s.

The absorption rate is supposed to be quite high (predicated on the carrier lipid), but it bypasses the liver, which is where delta-9 gets converted to 11-Hydroxy-Δ9-THC, this metabolite of delta-9 THC is the major psychoactive portion that gets you high. (it's also the PRECISE metabolite they are testing for when you are urine tested!)

So bypassing the liver should allow higher plasma and tissue levels without being a blithering idiot

@fernand this link is interesting! how involved to convert into an acetate?

if any of you are around the burn areas, stay safe! The 1st day of actual rain in CA and now begins the OTHER downside of these fires. More powerful storms lined up until thursday night

 

[Sick Vape]

I believe C No Ego is correct here.

this site/page is interesting: https://cannabiscure.info/cannabis-suppositories/

Originally conceived of and patented by the Israeli 'Father of Cannabis', with an accompanying paper in the Lancet in the '90s.

The absorption rate is supposed to be quite high (predicated on the carrier lipid), but it bypasses the liver, which is where delta-9 gets converted to 11-Hydroxy-Δ9-THC, this metabolite of delta-9 THC is the major psychoactive portion that gets you high. (it's also the PRECISE metabolite they are testing for when you are urine tested!)

So bypassing the liver should allow higher plasma and tissue levels without being a blithering idiot

@fernand this link is interesting! how involved to convert into an acetate?

if any of you are around the burn areas, stay safe! The 1st day of actual rain in CA and now begins the OTHER downside of these fires. More powerful storms lined up until thursday night

Thank you very much for this info. It would be like inhaling cannabis without inhaling and the head high. Should be perfect for me as I really don't like the effect of eaten cannabis and my lungs would often prefer air only. And my short time memory would like to recover too I guess.
I will have to try (still don't buy it, i stubborn head in this case).
Is there anything known what happens with thc-a when administered in suppositories?


Edit:
Sadly they use a THC-hemisuccinate in the study, which I cannot easily make at home.
THC in fat does not get absorbed well rectally according to them.

And yes in europe many medicaments get sold as suppositories too, no taboo here. Just wash your hands, lol. And don't medicate in public.

 

[C No Ego]

Thank you very much for this info. It would be like inhaling cannabis without inhaling and the head high. Should be perfect for me as I really don't like the effect of eaten cannabis and my lungs would often prefer air only. And my short time memory would like to recover too I guess.
I will have to try (still don't buy it, i stubborn head in this case).
Is there anything known what happens with thc-a when administered in suppositories?


Edit:
Sadly they use a THC-hemisuccinate in the study, which I cannot easily make at home.
THC in fat does not get absorbed well rectally according to them.

And yes in europe many medicaments get sold as suppositories too, no taboo here. Just wash your hands, lol. And don't medicate in public.

yeah, the reports I've found coconut oil is used in gel cap with the cannabis oil mixed into it @ volume. then the caps get put in freezer. they are frozen for rectal insertion... you have much more absorption capability down there without your digestive juices/ bile acids getting in the way and also less of that 11 hydroxy conversion that makes people see angels. for women a vaginal suppository does the same thing ETC....
I found this info out looking into RSO and cancer... people having to much psycho activity from ingestion in the mouth while trying to work up to one gram of activated oil daily... the same people found they could go up to three grams in the rectal suppository route with way less to no psychoactivity...
Edit - go to Grasscity.com and look up the hash oil threads where RSO is made into caps and such... too - Bad kitty smiles world summit https://duckduckgo.com/?q=Bad+kitty+smiles+world+summit&t=ffcm&atb=v62-6__&ia=videos

edit 2- explained - Bile acids and cannabinoids https://duckduckgo.com/?q=Bile+acids+and+cannabinoids&t=ffcm&atb=v62-6__&ia=web