The tolerance and withdrawal points might seem substance-oriented, but most of these effects can also be seen with THE greatest dependence problem of today: Social Media abuse. It's spread all over the world and we've become completely desensitized to it. We no longer even notice it.
Go to any public place and look at the typical people sitting or walking with a smart-phone in their hands, facebook'ing, instagrammin', twittering. They don't talk to each other, they don't even notice what's going on around them. Now imagine for a moment that they are all intravenously injecting themselves. You know, the men tying off the arm with a belt, the women with a scarf, then carefully positioning the needle in the vein, checking for the drop of blood as they pull back the plunger, and then pushing it in for that dopaminergic kick reward. Over and over again. Quite a sight, not all that appealing. Well, that's exactly what's happening with the Social Media junkies, and not just "every day". Many times a day. And sure as shinola they can't give it up.
But why? Because the advertisers have created self-tuning algorithms whose task was to figure out how to maximize clicks and page-views. And they have. The result? Widespread dependence that devours young lives, that robs users of real social interaction and sucks them into a fantasy reward system so they can be fully profiled, set up to watch ads, and buy the shit they sell.