I like Herbert however he is a (brilliant) science fiction writer not a scientist. He has no degree whatsoever, never graduated college. In many cases I'd say big deal, advanced quantum and astrophysics is so tough to grasp without the background knowledge. It's interesting and fanciful speculation but I disagree that it casts what we actually know to the wind. YMMV.
You miss my point. I'm not suggesting that Herbert is presenting anything like credible science. He is creating entertaining and exciting fictions of one way the future could look. What I got from Herbert, at 16 or so when I first read him, was the idea that we had no idea what we don't know and that something like folding space that seems preposterous to us now could possibly be not only reasonable but even less unbelievable than other things that turn out to be real. I think it was Arthur C Clark who said "any sufficiently advanced technology would be indistinguishable from magic".
How would the shuttle program or the ISS have looked to people just a couple hundred years ago. There may be civilizations out there millions of years old, or even more. We've been working on space since what, the 50s? Einstein theorized the laser in something like 1914, but it took till 1960 to build one. We're likely babies compared to other civilizations.
I'm just saying that I have absolutely no evidence that interstellar travel is possible and little convincing evidence that we have been visited by extraterrestrials of any kind, but like Dr. Becky in that video I have absolutely no doubt that we are not alone in the universe, and if that is true there is no reason to doubt that some of those civilizations are likely Ancient with a capital A. And look what humans have done in just a few hundred thousand years or less.
The laws of Physics are immutable, until we break one.