Quetzalcoatl, it's starting to be shown it's the essential oils that are giving these effects, not the THC or CBD. This is why some sativas do help you relax, and some indicas get you going. As far as CBD interacting with THC, CBD slows down it's metabolism, allowing THC to stay in your system longer. It also prevents some THC from binding to the receptors which is why you get the creeper high with cbd rich strains. But most CBD effects the CB2 receptors which are in the immune system. They down-regulate pain causing cytokins, and allow for more pleasure to be felt. People who feel a lot of pain tend to have a lot of pain causing cytokins. This is why it's important to eat high CBD strains or even if they have around 2-3%, because vaping or smoking doesn't allow the CBD to get into immune system effectively. Eating allows it to be more effective because most of your immune system is in your gut. Eating monounsaturated fats, help the absorption happen even more.
http://canchewbiotech.com/pain-management-and-cbd
"In a recent Scientific American article, chronic pain and CBD's are discussed citing when an injury takes place, increased Glial cell production forms around the neuro junctions. These Glial cells produce Cytokines which are chemical transmitters spreading inflammation and signaling pain. When a molecule of CBD binds to the Glial cell, the cytokine production decreases and the patient feels a marked decrease in pain. This would also explain why some patients have pain relief that lasts way beyond the theoretical effect of the CBD."
Here's information about pain causing cytokines:
http://www.mdbiosciences.com/blog/b...ines-as-potential-targets-in-neuropathic-pain
EDIT: I just found something that is groundbreaking, and that is the sympathetic nervous system increases the pain causing cytokines. This is very important for vaporist/smokers who like thick vapor, because when you inhale a thick vapor without a lot of fresh air after the inhale you are constantly activating your sympathetic nervous system due to the body thinking oxygen is low. For medical patients, this isn't good in the long term because it means you may never cure the pain, and may be making it worse the older you get. For recreational users, it means you will start feeling more pain as you get older. This can be avoided my inhaling as much fresh air as you can once you take in that thick vapor, because this allows your parasympathetic nervous system to become activated, and prevent too much activation of the sympathetic branch which means not activating too much pain causing cytokins.
http://www.ncbi.nlm.nih.gov/pubmed/20018617
Cutting edge: Sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis.
Although the sympathetic nervous system innervates the lung, little is known about its participation in host immunity to pulmonary pathogens. In this study, we show that peripheral sympathectomy reduces mouse morbidity and mortality from influenza A virus-induced pneumonia due to reduced inflammatory influx of monocytes, neutrophils, and NK cells. Mortality was also delayed by treating mice with an alpha-adrenergic antagonist. Sympathectomy diminished the immediate innate cytokine responses, particularly IL-1, which was profoundly reduced. These findings demonstrate an unexpected role for the sympathetic nervous system in innate antiviral immunity and in exacerbating the pathology of a virus of great significance to human and animal health.
) one of the things I really like about the MiniVAP so far ... I was about to post about that and think I might head over to the MiniVAP thread and post something there about it ... but I've really liked it as my primary vape for the last few days and was sitting here pondering the fact that the almost pure convection aspect of it coupled with the really quick extraction capabilities and ability to maintain temperature with any draw speed really give me the medication effect and taste I'm looking for ... still love my Cloud but like SliM has commented ... the MiniVAP doesn't seem to get as much of the CBD's ... same as the Volcano ... and I concur with this analysis.
