only thing we dont know is what the "proprietary extracts" areDarwins Headstash Herbal Incense Ingredients: Coltsfoot, Damiana, Ginseng Leaf, Mullein Leaf, Red Clover, Wild Lettuce and Proprietary Extracts.
True, we don't know what those extracts are, but is it safe to inhale the vapors from the items listed above? What may be safe for our stomach may not ba safe for our lungs. Just thinkin'.............claypool said:only thing we dont know is what the "proprietary extracts" areDarwins Headstash Herbal Incense Ingredients: Coltsfoot, Damiana, Ginseng Leaf, Mullein Leaf, Red Clover, Wild Lettuce and Proprietary Extracts.
I completely agree, people don't know the adverse effects of all these "herbal blends", for all I know it could be terrible for myself. Ill stick to the plant with tested results .lwien said:You know what's weird about this? We have got into long debates over the various materials that are used in our vapes, from brass to stainless steel, to ceramics, to plastics, etc etc etc, and we question how safe it is when our vapor comes in contact with these various things, but do we question what it is, in fact, that we are actually vaping? I'm not suggesting that there is anything dangerous in Darwin's Head Stash, but in looking at their site, there is no explanation of exactly what is in this stuff, so do we know for a fact that it is a safe product to consume?
Lots of dispensaries here in Cali sell some pretty tainted weed also, like in not properly flushed and when you light it, it's like the 4th of July. Got to just pick the right dispensary in order to get clean meds.collegerower said:My problem here is that unless you are growing your own, or get it from a dispensary, you do not really have control over your weed either. In fact a commercial product to me seems safer than a shady deal done with a complete stranger that wants to make money off of you.
LOL . We're all gonna die !!!collegerower said:See, even lwien looses!
None of us are safe!
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This makes me cringeBy ordering from DarwinsHeadstash.com the customer agrees to assume all responsibility to abide by applicable laws. The customer understands that s/he is under full liability for any personal injury, property damages, or other damages sustained either directly by his or herself or indirectly by another, that may result from the purchase, use, or misuse of any product from DarwinsHeadstash.com
I've seen some LD50's on the chemical. Very safe with a very low toxicity (on par with the cannabinoids in cannabis). Metabolites have been shown to be safe too. I can grab some links for you later, but in the mean time just google "JWH-018 safety".tdavie said:I wouldn't touch this stuff with a 10 1/2 foot pole (cue sound of The Grinch). I took a peak around, and it seems as if this stuff is an agonist (meaning it is attracted and binds to) the same cb1 and cb2 receptors as the cannabinoids that we know and love. No problem, right?
Well, when you have a enzyme substrate interaction, you generally have conformational changes in the enzyme (receptor here, while cannabinoids or JWH-018 are the substrate) that leads to a biological cascade of effects. Because they both bind to the same target (in this case receptor), JWH-018 and cannabinoids may be said the be competitive substrates. This per se doesn't mean squat, but if you took some JWH-018 and then later vaped some herb you *might* find you don't get as high as you did before. Why? Perhaps because JWH-018 is still receptor bound, or perhaps because the receptor is still in a different non binding position.
Bottom line is....until I knew the half life of elimination of this synthetic agonist from the body, there is no way in hell I would touch it. Safe? Dunno. I don't know of any peer reviewed studies that have demonstrated LD50's. It's a gamble as to what it does or does not do on a molecular basis.
Tom