I've had similar experiences, with chest pain and discomfort, mostly when I first started vaping.
I think that there are several factors involved. Everyone's body is different, and everyone reacts differently, to different things.
Strains can act differently, depending on how they are consumed.
The type of vape, temp, method, session length, etc.
I also believe, however, more than anything, that it is in fact, your body's response to a lack of combustion. When we combust, we cause damage to the cilia of the lungs. (The cilia are like waving fingers, moving things along - getting the gunk up and out of there). When we continue to combust, the cilia don't have the opportunity to grow back / heal /regenerate, so the gunk builds up.
When we abstain from combustion, the healing process begins…and we all know that healing can be painful or uncomfortable. Our body is working over-time, to try to clean things up, and get you back to normal. Even though it's a physical/physiological issue, it's similar to a withdrawal, in that you often become 'sick before you get better'.
That being said, I have a very sensitive respiratory tract. If I take too many hits, use a crappy vape, let it get too hot, take the material too far, or vape too much in general, then it also doesn't feel great.
You may also consider down-regulating (consuming less, or even no material, for a while), so you're tolerance isn't as high.