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The only way I can feel the effects of CBD is indirectly, e.g. by the reduced THC sensation. It seems to last as long as the other cannabinoids. Oh, yay @Penny Wise, thanks! Glad you reminded me, I have an eighth of 28% Red Congolese in ye Olde Stashe. I've been coming to the conclusion that...

The tolerance and withdrawal points might seem substance-oriented, but most of these effects can also be seen with THE greatest dependence problem of today: Social Media abuse. It's spread all over the world and we've become completely desensitized to it. We no longer even notice it. Go to any...

From observation, it seems that high CBD isn't as good on mood and nausea. As to the cancer itself, who can say, every cancer cell type responds differently. Very few lab studies (even) have tried to pin down what cancer cells are more sensitive to which cannabinoids. We got very good results on...

Test of postimg.cc BTW, what is that white wet cotton under the mesh heater? Still my fave one hitter. @Accept is right, if you match the voltage to the coil, no need real for temp control on a one hitter. Of course it never hurts.

As far as I read Epidiolex is isolated CBD. No entourage cannabinoids. That's what makes it FDA-acceptable, but so hard to dose, and why the doses are so high. IMHO it only makes sense for a patient in a zero cannabis region. Otherwise, buying fuller extract CBD should work at lower dosages and...

I wonder if GW publishes complete labs, like we can get with some prodding in California. I'd be curious to what degree they standardize all the wee lil' minor cannabinoids and "other non-cannabinoid components". It's hard getting everything to match harvest to harvest, and conversely if...

I wonder about Sativex. It's extracted from the plant, but it's hard to determine whether there's anything in there besides the stated approximately 1:1 THC:CBD.

The pharma products aren't really copies. They are constrained by regulations too, so e.g. a CBD product can't contain the very important entourage cannabinoids, making for a formulation that makes for unnecessarily high and difficult dosing. The others are single molecule or at most two...

One thing I've noticed is that many of the "medical is BS" clan are former alcoholics, or at least alcohol users. They laugh at micro-dosing and insist it's all about getting blasted. Anybody else notice that?

And then there are people who go to China on vacation or whatever twisted idea of fun leads them there, and they're coming from a cannabis-legal region. As part of the recent white devils campaign they will round up all the foreigners in a night spot and administer urine tests. Anyone showing...

Yes, but I don't think we understand what exactly makes each strain so different. First we had the CBD ratio theory. Then the terpenes theory. None of thse really work. If you look at full lab analyses, you can find very similar terpene profiles, and CBD ratios, in say a Sour Diesel and a...

I dunno. There's a temptation to fit things into a framework too soon. The lab observations so far are overwhelmingly complex. We've even seen cases of cannabinoids increasing the viability of cancer cells, although the vast majority of observations points to 1) selective increase in apoptosis...

At 50g of oil, that sure takes care of your min daily nutritional fat intake - and sludge output. There's a cult following for some organic cleanses that claim you can see some evil structures flushed out the back door. But it's the cleanse itself that aggregates into globules. They sell detox...

@Ricardo, you know, I've thought about what you said, and I'm not so sure about the "in your heart of hearts". People are just as likely to torment themselves as to deny problems. You can even see people here who are agonizing over using a little of a silly plant that grows all over the place...

Yes, they seem to have a good set of products, conscientiously analyzed and packaged. I don't imagine they are cheap. Do you know prices? And they are in Canada, and Federal US policies continue to create serious problems, to the best of my knowledge to this day, even going from a 100% legal...

Even in Calif where it's all legal, it's very hard to find full extracts. The readily available distillates are mostly THC flavored with terpenes from 50 gallon drums. Little therapeutic potential due to absence of other cannabinoids. You're right to advise mixing in some high CBD material if...

Yes, 5mg is more like it for me. But after a couple weeks adjustment, these doses are well tolerated. He was even making extra money by driving for one of the ride-sharing services. Long topic as to why these doses were used. Bottom line: so far so good.

Warmest sympathy and encouragement to anyone who's suffering cancer. I hope nobody is foolhardy enough to reject other treatment methods and only use cannabis. There is cellular level evidence to suggest that Chemotherapy and Cannabis can work better together than either one alone. I'm a...

Yes, sorry, I should have been clearer. I meant "garbage" as in "good shit, bad shit", and in contrast to all the money-motivated claims. By itself it's a strange bird, it's effective in seizures, and mixed with its brother and sisters of the cannabinoid clan, it's an important part of a...

Based on personal experience and trial and error dosing with a cancer patient. The reversal and blocking of THC effects have been been seen at the molecular level and anecdotally. The last published study I read was motivated by these reports, but under their test conditions they found it didn't...