Just a thought

[little maggie]

We know there are a lot of positive medical effects from cannabis. And (unless this is a misperception) we have receptor sites for cannabis- one being related to anandamide.
I've been aware for decades- even when I couldn't use any cannabis products- that my brain gets reset so that functioning is improved. I don't even need to vape daily for that effect to last. Otherwise I end up being spacy and a bit mentally disorganized and more depressed even though I take antidepressants.
So I've been wondering if some of us have a deficit in whatever the cannabis neurotransmitters are just as some people have a deficit in serotonin or dopamine.

Any thoughts about this?

 

[C No Ego]

We know there are a lot of positive medical effects from cannabis. And (unless this is a misperception) we have receptor sites for cannabis- one being related to anandamide.
I've been aware for decades- even when I couldn't use any cannabis products- that my brain gets reset so that functioning is improved. I don't even need to vape daily for that effect to last. Otherwise I end up being spacy and a bit mentally disorganized and more depressed even though I take antidepressants.
So I've been wondering if some of us have a deficit in whatever the cannabis neurotransmitters are just as some people have a deficit in serotonin or dopamine.

Any thoughts about this?

after looking into this for years... the conclusion and facts... cannabis use adds vital cannabinoids to our ECS (endocannabinoid system).. we synthesize our own endocannabinoids from EFAs lipid fats in our body... we do not make lipid fats though and they are dietary required fats gained from the food we consume... because our entire human biology relies on this pliable lipid diet required carbon fuel to thrive I'd say it is an evolutionary derived organizational system using the most abundant fuel- carbon...
the ecs is proven too for the most part... our cells have lipid coatings that allows them to exist... these lipid coatings of the cell membrane needs to communicate inside the cell http://www.bionity.com/en/encyclopedia/Cannabinoid_receptor.html.. this is where the cannbinoids come in.. the cannabinoids are tiny little crystals that have the exact shape to trigger a physiological response upon cell receptors.. they are termed neuro modulatory lipids.
http://www.phytecs.com/tour-the-ecs/cannabinoid-signaling-at-the-synapse/

our deficiency is from not eating the correct types of omega fats from our food to maintain the lipid flow in us... we synthesize the endocannabinoids from the omega fats, arachidonic acid to be exact is what becomes endocannabinoids...

 

[little maggie]

This is interesting but confusing. I looked up arachidonic acid and read that it should be avoided by people who have joint or inflammation problems because it will make them worse. Which makes no sense given that cannabis helps with inflammation.

Also still looking, without success, for what foods contain it. Lots of supplements but not list of food.

 

[C No Ego]

This is interesting but confusing. I looked up arachidonic acid and read that it should be avoided by people who have joint or inflammation problems because it will make them worse. Which makes no sense given that cannabis helps with inflammation.

Also still looking, without success, for what foods contain it. Lots of supplements but not list of food.

I'm still confused too LOL but see the light at the end of the tunnel... apparently precursor arachidonic acid (AA) is made from omega 6 and omega 3 so our out of balance omega 6 is making to much out of balance AA that needs the omega 3 to balance it... I think an easy formula is , we need 6 parts omega 6 to 1 part omega 3 or 6:1.... western diets are 20:1 or close which makes to many omega 6 precursors... I personally keep a gallon of organic hemp seed oil on hand and take it whenever I feel like it throughout the day... hemp seed oil already has naturally correct efa balances of the 3,6, and 9 proportionately speaking...if you get that large a quantity @ once use small amounts and store/freeze the amounts you are not using, it's a high oxidation oil that can go rancid easily...
here is some links to help explain it

"Arachidonic acid is the precursor that is metabolized by various enzymes to a wide range of biologically and clinically important eicosanoids and metabolites of these eicosanoids:"
https://en.wikipedia.org/wiki/Arachidonic_acid#The_synthesis_and_cascade_in_humans

https://en.wikipedia.org/wiki/Essential_fatty_acid_interactions

"LA is a polyunsaturated fatty acid used in the biosynthesis of arachidonic acid (AA) and thus some prostaglandins, leukotrienes (LTA, LTB, LTC), and thromboxane (TXA). It is found in the lipids of cell membranes. It is abundant in many nuts, fatty seeds (flax seeds, hemp seeds, poppy seeds, sesame seeds, etc.) and their derived vegetable oils; comprising over half (by weight) of poppy seed, safflower, sunflower, corn, and soybean oils."
https://en.wikipedia.org/wiki/Linoleic_acid

https://www.sciencedaily.com/releases/2017/07/170718142909.htm

http://www.pnas.org/content/114/30/E6034

http://themedicalbiochemistrypage.org/omegafats.php

http://nutritiondata.self.com/topics/fatty-acids

https://www.ncbi.nlm.nih.gov/pubmed/12442909

https://www.ncbi.nlm.nih.gov/pubmed/21278728

this is probably the best to explain omega 3 and cannabinoids
http://themodern.farm/studies/Omega-3 Deficiancy Abolish Endocannabinoid Function.pdf

as to your inquiry about brain functioning and plasticity
The Endocannabinoid System: A Putative Role in Neurodegenerative Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070159/

 

[MinnBobber]

So I've been wondering if some of us have a deficit in whatever the cannabis neurotransmitters are just as some people have a deficit in serotonin or dopamine.

Any thoughts about this?

..............................................................................................................................................
IMO, based on studying our ECS, it's a rare person that has a full functioning Endocannabinoid System. I petitioned our State (MN) to add ECS Deficiency as an approved medical condition.

First, for our body to produce it's own (endogenous) cannabinoids, it needs the right building blocks in one's diet, like proper Omega 3's etc. Right there, 95% ?? of us fall short.
Modern life assaults our ECS daily with stress, lack of sleep, lack of exercise, toxic chemicals, poor diet/too much processed food ,insecticides, pesticides, fertilizers, microwaves, excessive noise. All our systems (ECS included) fall "off" somewhat as we AGE so that's a big part of it too.

Some don't have enough endo-production of internal cannabinoids. Some don't have enough ECS receptors as they go away if not used regularly (side note--that's why some first time cannabis users don't get high as they lack receptors, which then form after/in response to some cannabis use). Some have ineffective receptors which just are not as efficient as they should be. So, there are MANY links in the ECS chain that can go wrong/ not work properly.

That's why cannabis is the ultimate "daily supplement", cuz almost everyone's ECS is coming up short, from a wide variety of reason/causes. Almost every person would benefit from a daily microdose of phytocannabinoids (cannabis) .

Here's another clinical example regarding ECS deficiency, an excerpt from my petition to add autism spectrum disorder:

"There is a fascinating study from Stanford Medical Center 2013 dealing with the autism gene, a mutant NL3 gene. This would be a similar concept to the mutant breast cancer gene which greatly increases the chances of breast cancer, whereby some women with this gene even get a double mastectomy. The study showed that having this NL3 gene was a link to autism and a decreased secretion of endogenous cannabinoids."

Deficiency of endogenous cannabinoids will likely be associated with almost every disease IMO.
ECS is the key to balanced body systems and disease resistance. It's the reason why cannabis can work on dozens of diseases, seemingly an impossible task.

 

[mephisto]

Thanks all for the information, fascinating stuff!

 

[MinnBobber]

Thanks all for the information, fascinating stuff!

.................................................
I am fascinated by the ECS as IMO it's the biggest med discovery in 50 years. It's like a massive- neurotransmitter/receiver , chemical, electrical, organic , super computer. And controller of most body systems at system-wide AND cellular-narrow levels, .... and our only electro-chem system that flows both directions, to give feedback so ECS can direct adjustments to get back to homeostasis/balance.

Most of us here know how well cannabis can work for so many conditions. Knowing the ECS helps answer the next question: how can one natural flower possibly help so many diseases?
Hey, everyone keep fighting to make it legal for all

 

[little maggie]

So interesting. It's too bad that research has been delayed so long because of politics. I hope that they start research on the effects of cannabis on alzheimers as well as the senior brain.

 

[MinnBobber]

I hope that they start research on the effects of cannabis on alzheimers as well as the senior brain.

..................................................................................
All indications point to cannabis helping with Alzheimers, like a study from Bonn, Germany with special mice, memory tests, and cannabis.
These lab mice have short lives and their memory fades when they reach "senior status"/as they age.
With microdoses of THC, not only was this memory loss stopped, it was reversed to where they had the memory of a juvenile mouse

https://www.uni-bonn.de/news/128-2017

Being there is no current med that works for the disease, and being that cannabis has almost no side effects, in a sane world, based just on this study and knowledge of the ECS, we should be giving cannabis to anyone with dementia/alzheimers or pre-alzheimers at a bare minimum. Or better yet, cannabis to anyone that cares to take the world's most potent health supplement for preventative medicine...

 

[psychonaut]

I've been taking an good omega-3 supplement this month and feel like it's helping a lot. There is a lot of information out there regarding our omega imbalances. I don't eat a lot in my diet of natural omega-3's and think just about everyone who is not a big fish or greens eater to supplement it.

 

[C No Ego]

Damn @MinnBobber = U Go Girl! I'm going to be trying to keep up with U now! @little maggie @ least we can be the ones to bring this info forth to open the publics eyeballs to See A New...
@psychonaut - a quote from that omega three farm study

"
Lipid molecules are the building blocks of the central nervous system (CNS). In
contrast to other tissues, the CNS and retina are enriched in polyunsaturated fatty
acids (PUFAs): arachidonic acid (AA, 20:4n—6) and docosahexaenoic acid (DHA,
22:6n—3). These long chain PUFAs are indispensable to the normal development
and function of the CNS
1
. Linoleic acid (18:2n—6, LA, the precursor of AA) and
α
—
linolenic acid (18:3n—3, ALA, the precursor of DHA) are not synthesized de novo by
mammals and a balanced diet containing appropriate amounts of these precursors is
obligatory to maintain sufficient brain levels of long chain PUFAs
1,2
. Brain and retina
DHA decreasee resulting from nutritional deficiency or aging are associated with
reduced cognitive ability, increased emotional behavior and decreased vision
3
.
Despite their high caloric contents, wester
n diets are poor in essential nutrients and
notorious for their low levels of n—3 and high levels of n—6 PUFAs
4
. Fetuses and
newborns exclusively rely on their mother’s diet for their PUFAs intake. Indeed, major
structural fatty acids such as DHA that cannot be efficiently metabolized by
developing babies must be received from the mother through the placenta during
pregnancy and through breast milk during nursing. Finally, the deleterious
consequences of maternal malnutrition on the progeny are further aggravated by a
lifetime of nutrient poor diet."


the crazy part here... people who get their omegas right are always naturally high, lol... IMO, with correct diet we will not have the "high" effects from cannabis use like we know of it now...

arachidonic acid explained mon - copy and paste into you tube
Arachidonic acid in 10 mins or less

 

[C No Ego]

instead of editing this in above...

I think I got it- it seems confusing but the arachidonic acid AA ( omega 6, AA) is cleaved off of the cell membrane and metabolized for cb2 receptor functioning , the same receptor that CBD acts on... this cb2 metabolic action potential actually works like FAAH http://www.bionity.com/en/encyclopedia/FAAH.html by slowing down cb1 signalling metabolism which is the receptor that THC acts on or where omega three, DHA) is synthesized... there is a certain level or amount though where too much AA acts the opposite like in western diets etc... I think that explains it, if anyone knows something else please add it to the discussion- Peace

the synthesized PUFAs communicate via whats termed 'crosstalk" on the cell membrane

 

[C No Ego]

@little maggie I'm not sure I answered your original question about AA making inflammation... We need inflammation ( inflammatory compounds) in amounts that trigger our anti-inflammatory response... I think this is the importance for proportional amounts of omegas... so we do not get over inflamed.. but without inflammatory reactions our cells would go placid and dormant and lack resistance... so a healthy amount is needed..

 

[jojo monkey]

https://en.wikipedia.org/wiki/Hypofrontality

You ever hear of this? Seems to be a blood flow view of many mental probs.

 

[JmVape1988]

Health benefits is more important so you need to ask your health practitioner the right amount.

 

[C No Ego]

https://en.wikipedia.org/wiki/Hypofrontality

You ever hear of this? Seems to be a blood flow view of many mental probs.

that would not be a problem with cannabis use... cannabinoids as secondary metabolites regulate calcium ions on cb1 receptor and modulate glutamate @ cb2 receptor... the condition you mentioned was a problem with Glucose which cannabinoids regulate IE homeostasis