More diffusion means more room for loss of flavor and potency. Doesn't mean that you can't optimize to avoid condensation. Upping the piece and water temperature to 30°C, using anti stick solution with bi-distilled water, helps avoiding potency loss, there is less stuck in the piece and more going to your lungs.
I like diversity. When I want a huge rip for a quick medication I'll go for the biggest and more diffused piece, when I want to take my time and enjoy the taste I'll go smaller.