Btw, that *is* a problem. Only recently (I think) a discussion among pharmaceutics began about the differences in dosages for men and women.
As such quantifiable but this is really not what I'm trying to learn more about.
" Lipid-soluble compounds are rapidly absorbed presumably because they can integrate into the lipid bilayer surrounding the cells. This constitutes the “transcellular pathway” in which compounds pass from the apical to basolateral side by traveling through the cellular membrane. "
" there appears to be no species differences in the rates of absorption of lipophilic drugs "
" The volumes of solution injected intratracheally were approximately 2% of lung volume. At various times after drug administration, the lungs were removed and assayed for unabsorbed compound. Although the 12 drugs studied had widely different absorption rates, each was absorbed approximately 2 times more rapidly when inhaled as an aerosol than when administered by intratracheal injection, suggesting that absorption may be more rapid from the alveolar region than from the tracheobronchial region of the lung. "
" At various times after aerosol inhalation, the lungs were removed and assayed for the amount of compound that had not been absorbed. The times (min) necessary for 50% absorption were: antipyrine, 0.25; salicylic acid, 0.67 " -https://pubmed.ncbi.nlm.nih.gov/6137343/
Interesting that the salicylic acid takes .67(half this if administered via aeresol) minutes for 50% absorption on mice, I'd say it's not far fetched to say it'd be similar enough to THC, although some studies say bigger molecular weight increases absorption speed. So far nothing on the dosage variation on absorption.
Another interesting fact(wonder what these devices are):
" Traditional aerosol devices can only deliver about 10 to 20% of their loaded doses into the lungs. Thus, if a protein has an in-lung aerosol bioavailability of 50%, but the device that is used to deliver the protein has a delivery efficiency of only 10%, then the overall delivery efficiency (bioavailability from the device) will be 5%. "
Dronabinol | C21H30O2 | CID 16078 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov
Salicylic Acid | HOC6H4COOH or C7H6O3 | CID 338 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov