I've only lived on the West Coast, so my frame of reference may be screwed up. I've lived on the boarder between Oregon and Washington since 1973.
Portland is about an 1 1/2 hr to the coast, 1 1/2 to 2 hours to Mt Hood (skiing). Its located at the confluence of two rivers: The Willamette and the Columbia (the third largest US river). Salmon fishing is big. The city is small by US standards, which is a plus, and it seems to me to have the stuff I like. I like music, and Portland seems to be a regular stop for musicians. I like the availability of traveling Broadway plays (Best of Broadway series). Portland has an opera and a symphony, if that's important to you.
The people seem friendly, prejudice is more covert. You have to get used to rain. I think the average is 37.5 inches a year. It was a drought year my first year, and, coming from the San Francisco Bay Area, It seemed to me that it rained every day.
Because sunny days are fewer, when its nice, its incredibly nice. You can see Mt. Hood from many Portland areas. The Summer months, to me, seem to start in July and go through mid October. The Spring (like right now) is an incredible riot of color. Rhododendrons and azaleas love the rainy, acidy soil. I love driving through mature neighborhoods. But guess what? Its overcast. Grey becomes your new sky color.
The winters are mostly mild, I suspect, compared with Ohio. Its a kind of a Marine climate, what with the Columbia River and being so close to the coast. It may snow a few days or not at all in this northern part of the Willamette Valley. It snows in the surrounding mountains.
I am a Washington resident, so I know nothing on the medical pot aspect, but there seems to be plenty around as to availability.
As to prices, I suspect housing is more expensive than Ohio. Its cheaper than California. But then, practically everything is cheaper than California. Beautiful coast. No hurricanes, rarely a tornado, we got earthquake faults. Like many places on the West Coast, they say we are overdue for the "Big One".
Washington has no State Income Tax. Just a sales tax. Oregon has no sales tax, but has a State Income Tax. Property taxes, as a rule, are cheaper in Washington. If you work in Oregon, but live in Washington, you still pay Oregon Income Tax.