Hey mattend, you can grind it wiry a hand grinder if you do everything very cold and fast, the quality wont differ if it is fast/cold enough because of the nature of Iso as a solvent. I mean -10°f exposed for <10 seconds and it will have no difference if it is broken up or not except to maybe increase yeild. But it must be a hand grinder, coffee grinder is too powerful.
And I agree with smokum, its all about what works for you. You could experiment some, just remember once the Iso is gone your only ingredient is weed, so its not a waste when made, it'll always be stronger than the starting material. If initial does come out undabable by your own opinion, you could always cook it into a brownie.