Psilocybin helps a lot of people as well.
Funny enough I wanted to mention the same a few hours ago. In all fairness, the clinical research is somewhat sparse at this point, but the case reports are plenty and virtually all existing literature looks extremely promising. It is kinda the way the psilocybin depression literature looked 7ish years ago. Bizarrely promising probably sums it up the best. One obvious factor here is the usual "the war on drugs has ruined everything" problem, if we had data as promising for a different pharmaceutical agent that didn't lead to altered states of consciousness, there would be more public interest than in covid vaccines (maybe ). The effect sizes psilocybin achieves in depression trials frankly look outlandish to anyone familiar with the effect sizes you see for routine psychotropic agents. I have been diagnosed with something called new daily persistent headache, essentially I had a viral infection about 2 years ago and since have not had a day without headache (with no real headache issues before that), as well as a fun array of weird auto-immunity and inflammatory issues. I went from fairly high achieving young scientist who did 2-3h of combat sports 5 days a week to sad fuck who lies around with the shades drawn because photophobia is a bitch, worrying about what if I am on my way to permanent disability. So not very fun. I had previously taken psilocybin as a tool for introspection/mental health management and found it extremely beneficial in that realm. After a bit more than a year of everyday headache my mental health had gotten pretty bad and I felt it necessary to engage in some internal housekeeping, so I took psilocybin, pretty much in a style as is used in clinical settings/research. That is, lie in bed, have the option of fairly "nice" music (i.e., primarily slow but upbeat instrumental/electronic stuff) and just kinda meditate on a medium dose. See what pops up kinda thing. With persistent pain it can be a pretty heavy trip, lots of difficult emotions you may encounter. So that initial trip seemed useful in the psychological regard, but what I had not at all anticipated was that it impacted my headaches. It pretty much halved the intensity within 2 days, so that some days I was almost pain-free, and the effect lasted for about 2ish months. Had a few more of those experiences since then, and whilst certainly psychologically difficult (as in, it can be really hard work and the processing takes time), I am profoundly grateful to have discovered this option. It's been about 4 months now since the most recent trip, and I'm pretty sure I see a stable adjustment downwards (say compared to 1yr ago).