I gave them a shot, I haven't used one in a long time and don't plan to get more for myself going forwards. They're a little bit expensive for the medication delivered, IMHO, but they have very real benefits for certain people that need a long extended release mild dosing.
http://fuckcombustion.com/threads/marys-medicinals.17221/
I found the effects of most versions I tried to be mild, relaxing, but not tiring; some of the blends were nice, that i took during a flare up of some shoulder and back pain, because as soon as I lay down I was asleep when my head hit the pillow instead of rolling around for a few minutes. Don't know if that was direct causation but even after vaping before bed I wouldn't have the same physical relaxation as the patches provided me. For me that means more like a medible compared to vaping's effects.