Kimosabe
Educator/Cannabis Evangelist
It was in a slide show sent to me for review. Shocker. Power of suggestion?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533883/
first pass liver effects on cannabinoids/ THC ??
- Thread starter MinnBobber
- Start date
It was in a slide show sent to me for review. Shocker. Power of suggestion?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533883/
C No Ego
Well-Known Member
The idea - CBD non selectively antagonizes cb2 receptors... this engages them... THC then can non selectively agonize cb1 better thereafter...
this action works better with beta caryophyllene - beta caryophyllene is a dietary cannabinoid https://duckduckgo.com/?q=beta+caryophyllene+is+a+dietary+cannabinoid&t=ffcm&atb=v165-1&ia=web
BCP is a selective agonist @ cb2... BCP directs the action better than CBD ETC... so that THC can then interact with cb1
here is a thread explaining it from a long time ago
https://forum.grasscity.com/threads/cannabis-black-pepper.1282798/
Interesting. So I could use Pepper instead of CBD, when I do not tolerate CBD well.
I wonder how big the dosage has to be to block most CB2 receptors.
So eating a mix of pepper and cannabis should give a stronger high and if you are very high you can tame it down by eating some black pepper?
I was always told alot of traditional cannabis edibles like majoun or bhang lassi contained pepper. Might be because of the above. While I ate edibles containing pepper in the past I never made a comparison with no pepper.
I now just tried eating 5 black peppercorns before vaping. Gives me the hiccups.
TheThriftDrifter
Land of the long vapor cloud
@Sick Vape for a moment there, I thought you were going to try vaping black pepper. 
C No Ego
Well-Known Member
Interesting. So I could use Pepper instead of CBD, when I do not tolerate CBD well.
I wonder how big the dosage has to be to block most CB2 receptors.
So eating a mix of pepper and cannabis should give a stronger high and if you are very high you can tame it down by eating some black pepper?
I was always told alot of traditional cannabis edibles like majoun or bhang lassi contained pepper. Might be because of the above. While I ate edibles containing pepper in the past I never made a comparison with no pepper.
I now just tried eating 5 black peppercorns before vaping. Gives me the hiccups.
it is quite confusing and amazing at the same time... one of the main attributes of adding BCP into the cannabis mix is because of the half life of BCP... BCP has a 24 hour half life while THC is determined to be about 5 seconds... this is most likely because BCP is a selective agonist and THC non selective...
selective / non selective , selecting the pathway means the ligand will engage with more binding affinity to the cb receptors.
non selective will act more peripherally while a selective will directly engage. I've even seen mention that BCP is a reverse selective agonist
@TheThriftDrifter I have vaped fresh ground peppercorns mixed with cannabis... it can go wrong if the terpenes in the cannabis do not jive with the BCP... plants grow certain terpenes that match their profile ( entourage) and mixing them around can produce odd results. But, I had el cheapo weed with not much smell... added some peppercorn and it was ok, not that good though. better to eat it