hibeam
alpha +
Flawed studies like the above about CHS deaths can make me turn to bro science like this that at least tries to be scientific:
--http://www.tokecity.com/forums/archive/index.php/t-53103.htmlNot certain on this theory, but my belief is that this syndrome could be a result of THC being a 5HT3 antagonist. Agonizing 5HT3 triggers nausea and vomiting, antagonizing 5HT3 does the opposite, hence why cannabis is an excellent medication choice for those suffering from nausea.
I believe the problem to be that when you are constantly antagonizing 5HT3 through use of THC your body seeks to balance things out and create a level of homeostasis by either decreasing sensitivity of the receptor sites to the antagonizing properties of THC, or (more likely in my opinion), the body is countering with higher concentrations of 5HT3 agonists being produced to balance things out.
When a patient stops ingesting THC for a short break (roughly 8 hours of sleep), the body has continued producing its 5HT3 agonists to keep up with the supply of 5HT3 antagonists that you've been supplementing (so the body has also down regulated its natural production of these antagonists) and the patient wakes up feeling nausea. Remember that morning sickness is one of the major forms of diagnostic criteria involved in this syndrome.
A second important symptom involved in the diagnosis of this syndrome is the relief of nausea with frequent HOT baths/showers. Why would HOT, and specifically hot not warm help with nausea? My guess here is that it has to do with serotonins role in regulating body temperature. Not enough serotonin and the body has trouble maintaining temps of 98 degrees. Too much serotonin and the body overheats, as can be seen in serotonin syndrome. So, when a patient takes a HOT shower, my guess is the body sends signals to decrease serotonin, thus decreasing agonism of 5HT3 that was previously being overdone, causing temporary relief of symptoms.
Just a theory though, who knows.