Last night I tried 100 mg of 5-htp 1 hour before vaping with the extreme q. The mj was mid grade, it was about 8pm and I hadnt eaten anything since the day before except for a cup of coffee in the am. I am new to vaping but I have smoked mj everyday for the last 5 years. A session usually lasts for four to6 hours but up to 8 hours...daily. I can say that I didnt notice any difference in the intensity of the high or the duration. The only thing I will comment on, is that it MAY have kept me up a few extra hours but I am not entirely sure that it was the cause. I will try it again, but with little expectation that there will be any difference.