we'll see if that actually quotes you...
>> The CYP-450 mechanism is in play for opiates in particular (one of the reasons for the 25% drop in OD and deaths via opiates in legal cannabis states).
That is a pretty big claim !! i have never heard of that as a reason to the stastisical 25 % drop that we hear about in opiod deaths in places were cannabis is legal . and i doubt very much that is the reason at all . <<
ok, do a search, it's a study that's been quoted many times in the last year.
what exactly are your doubts about this being the reason, or even A reason?
>>Anybody i know that has a opiod adiction and i know a few . they alreay smoke weed, and pretty much any drug they can get .<<
I'm not gonna play games about who's known worse addicts... where do most opiod addicts start their addiction? In their doctor's office. FACT. As for them using other substances, yep they sure do... a constant dance of what they can get hold of and how they can use that to keep them 'in balance' (in their minds).
These days, if you play in those waters, you better have NARCAN on hand with you and someone trained in how to use it!
>>CBD works similar to grapfruit juice so if what you are saying was true people could just drink grapfruit juice for the same effect .<<
CBD works NOTHING like grapefruit juice (aside from acting on that enzyme) and has activity throughout the body via the body's endogenous endocanniboid system (ECS) and all the cannabinoid receptors sprinkled throughout the body, particularly the brain/nervous system/gi tract. Grapefruit juice cannot and does not do what CBD does. It's a stretch to even call it a comparison.
>>but here is the thing that effect is a potentiating effect mostly which means it maks it take longer for your body to get rid of the drug .
which leads to a build up of the drug in your system which is not a good thing espeicaly if you are a drug addict who is at risk of an overdose .<<
exactly WHAT are you calling a 'potentiating effect'? and why would it take longer for the body to excrete the drug? are you inferring that CBD is somehow changing the half-life of drugs???
>> Its unlikly that this is any reason at all for a decline in opiod deaths . and if the 25 % reduction is even true at all its more likly that people are using cannabis as a replacement type of thing.
perhapes they are allready trying to get off the opiods and they are now able to get legal weed and it helps because they can reach for it first and in that way helps .<<
And you came to this conclusion through what mechanism of the scientific method?
Cannabis as a replacement for heroin or oxycodone, they'd be beating a path to your door.
Exactly WHAT is it that you think Cannabis would replace for an opiate addict?
I'll ask again, so what is it about 'legal weed' (with our without CBD, you haven't made any distinction), that you think 'helps' them? (I don't think reaching for an inferior alternative has ever been on an addicts mind)
>>CBD could help people in pain lower there dose of opiods though but these are people that are probably not the ones at risk of death by overdose .
these are the people using opiods for legit reason . most of the deaths by overdose would be from addicts pushing the limits of the dose to the point of death .thats different . not to say that some of these people didnt get adicted to opiods for a legit reason to start with but ...<<
You have an interesting idea of who's at risk of OD from opiates! By your own admission some of the folks you previously labeled as 'addicts' became that way under a doctors care
It is in fact these people who are at greatest risk of OD, 'cause as they get cut off from previously legal accessible means (this is impacting legitimate pain management patients across the country), they seek the next most accessible means - THIS is where they get tripped up, as SO many street opiates are now cut with fentanyl, and just a wee bit of fentanyl can kill a good sized man. literally the size of a grain of fine salt is enough to kill you. Someone makes a slight miscalculation and it's goodbye to the pale blue dot.
>> Also the few people i know who are adicted to opiods and and abusing them , the ones with the highest odds of winding up dead from there addiction would not be at all interested in CBD they are wanting something they can feel an effect from .<<
That's sad, but not uncommon to most addictions.
Here, here's a way out, no... it won't goose your dopamine reward system for 8 hours, sorry.
I've watched to many people take a fall from this shit, sadly some of them permanent... on the other end of the scale, a bunch of cool folks with 20-30 year chips.
>> I also know someone who is using opiods for real pain reason and has been for quite some years . this person could possibly use less opiods with the help of CBD but they are not at any risk to beginn with .<<
I AM a chronic pain patient (among other things), I've been through the entire gauntlet of modern pain management... ironically, NONE of the opiates work on me (blew their minds) and they ended sending me to my 1st medical cannabis doctor (who was a cool dude, who did his homework).
I have friends who have hardware in their backs and have been on oral morphine, etc. for decades...
NONE of them will tell you that it's all cool. Chronic constipation, serious GI problems from it, surgeries, etc.
I had one patient like this try a dose of CBD around 40mg, they were able to move in ways that hadn't been able to for years. Converted on the spot, BUT!!... they have Kaiser. They love all their other doctors, and are willing to put up with no CBD until they change.
>> Anyway as far as the oridginal posters question goes ..
I can tell you i have been experimenting with high CBD strain for about 5 years now and to me its a very strange thing .<<
how high in CBD and THC is it? are the genetics stable? do you have labs? 'cause I'm more interested in the overall picture and what possible entourage effects could be present.
>>We hear all the time how CBD is suppossed to be good for anxity im my experience it sometime has worked for me but other times it has agravated my anxity.
I have used strains with like 2 % thc and 8 % CBD that has incressed my issues one day and the next helped
I can say the same with thc i have used strains with very high thc that helped me one day and sent me through the roof the next .
Also if i use high cbd strains for extended periods of time they start tonmake me feel very wierd not plesant at all a sick and anxious feeling that i dont remember having before ever using CBD strains .
You have tobremember everybody is different and if you are taking some other meds that are working on receptors in your brain that are desinged to or suppossed have an effect on your personnallity and you mix with pther drugs who the hell knows what your getting into<<
A high CBD low THC strain should not cause anxiety issues. You certainly shouldn't feel much @ 2%
When you say 'increased your issues one day and helped the next', what issues and how did it affect them (positively and negatively)? Same when you're talking about highTHC strains.
I know of no precedent (not saying it doesn't exist and hasn't been documented) to this cummulative effect of the CBD you're presenting here. Are these plants being raised ORGANIC??
Yeah, everyone has a different biochemistry, but that's also part of why the bell curve was invented!
These aren't just receptors in your brain, and what makes you think they are DESIGNED to have an effect on your personality? (personality persists, alteration fades)
I'm current undergoing chemo (yeah, again, this kind of cancer always returns... typically with a mutation), and per my last labs, I'll be increasing my CBD intake this week. I've been using significant amounts of whole plant extract, including CBD & THC for probably about 11 or 12 years now with no issues.
Tell you one thing, a good whole plant extract that uses a cold or room temperature process that preserves all the compounds... wow, the entourage effect is a powerful thing, quite unmistakable!
