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Cannabis Withdrawal Symptoms together describe the supposed Cannabis Withdrawal Syndrome which has various underlying causes. According to D’Souza et al. (2016) "Rapid Changes in CB1 Receptor Availability in Cannabis Dependent Males after Abstinence from Cannabis" -- Repeated exposure to...

I wasn't asking for random references, but this is what I have learnt: Complicated withdrawal may occur in people with concurrent mental health and polysubstance use. Cannabis withdrawal does not carry a high risk of severe adverse outcomes. The presence of medical or psychiatric comorbidities...

Any serious reference that is not from Reddit? Is there evidence that a normal cannabis user who is not stoned and not in withdrawal is any different from a normal non-user? Going from sustained heavy use to complete abstinence overnight is bound to be uncomfortable, so a gradual reduction (if...

In the case of CB1 receptors it is not true that "if the receptors are constantly filled by extrinsic molecules then the body will gradually produce more receptors", although the discomfort of withdrawal is caused or exacerbated by the rapid increase in receptor availability over the first few...

0.03g three times a week doesn't sound like much to me, but everyone is different. And I think counting receptors requires a post mortem examination, but PET scans have shown a reduced availability in the brain of heavy and moderate users. The endocannabinoid receptors have been shown to...

I don't think anyone disagrees that regular heavy use of cannabis can cause some withdrawal symptoms on cessation, but everyone is affected differently, and any physical symptoms should ease within a week. CWS is real, but at worst it is a passing "moderate illness". I think tobacco is more...

Not to mention the excellent hash oil that was coming out of India! (I'm remembering the early 1980s, and the story I was told is that someone who worked in a lab producing THC had taken his method to India, where the Cannabis supply is infinite) The article is fine, but it doesn't need to be...

Many original strains had 15-20% THC and Thai sticks (for example) were widely available long ago.

1967

The symptoms of cannabis withdrawal include irritability, anxiety, sleep difficulty, decreased appetite, depressed mood, and perhaps abdominal pain, shakiness, sweating, fever, chills, or headache in the first week of abstinence. The best way to avoid increased tolerance and any potential...

There is downregulation of CB1 receptors in the cerebral cortex of chronic cannabis smokers, but whether it is due to less receptors or a reduced affinity of receptors with their ligands is unclear. The lower availability (however it occurs) is directly related to tolerance. And the peak of...

Hirvonen et al. (2012) showed recovery in two weeks, but D'Souza et al. (2016) found that after only two days of abstinence the CB1 receptor availability was still lower but not significantly different from non-user controls. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742341/ If your...

The narrator says "when the brain is repeatedly flooded with T.H.C. it reduces the number of cannabinoid receptors" but no details are given. More generally, responses to reward-seeking stimuli are complex and individual experiences will vary. The Brain’s Reward System in Health and Disease...

My description of the receptors was informed by what I have read about opiate addiction, and I assumed that cannabinoid addiction would be similar. I am interested to know the details behind the brain's decision to reduce the number of cannabinoid receptors in response to THC, which would make...

Videos by Bruce Conner Mea Culpa - Eno & Byrne Mongoloid - Devo

This paper has been posted before, and if monkeys are trained to inject THC or anandamide in both cases they will choose to do it again and again.

Stainless steel contains chromium, and the surface reacts with oxygen in the air to immediately produce a fine layer of chromium oxide (which protects the iron from oxidation and makes the steel stainless). I always remove and replace my Old Mate's lid carefully and I'm pretty sure that the...

Anandamide and THC are both cannabinoids and some similarities have been shown in their effects on brain reward processes, but the two molecules are quite different in their structure and other aspects of their function - e.g. anandamide is intimately involved with programmed cell death...

I think that "the brain adapts by downregulating the cannabinoid system" is an oversimplification that could lead to misunderstanding. The various receptors work in concert to maintain the body's balance. An open receptor is one state and a filled receptor is another, and there is headroom for...

If mould spores are a problem, it should be noted that Cannabis is naturally associated with many different microbes, and a recent study (using a Volcano) found that: "While there were trends of reductions in microbial counts with heating, these reductions were not statistically significant...