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Micro-dosing

Discussion in 'Vaporization Discussion' started by stressed, Nov 20, 2015.

  1. archangelz001

    archangelz001 FIRE!!

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    @C No Ego
    To simplify - both black pepper (because it has beta-caryophyllene) and Cannabidiol (CBD) keep THC from binding to CB1 and CB2 receptors. The effect is that THC can't bind at those receptors and so the user doesn't get as high, or can come down somewhat if they feel paranoid or too spaced out from the THC. When you say that pepper and CBD slow down degradation of THC it seems like you are trying to say that the THC high would subsequently last longer. And black pepper can "substitute/supplement cannabis for micro dosing." I thought it was eating Mangos 45 minutes before vaping that accomplished that (because it has Myrcene). And my experience is exactly opposite in the sense that CBD keeps me from getting very high on THC. When I vape the THC euphoria is not as intense and doesn't last nearly as long.
     
  2. C No Ego

    C No Ego Well-Known Member

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    they slow down the time it takes for thc to have it's biochemical effect.. you say it is blocking thc but it's augmenting how thc can signal... of course you could take a lot of cbd and totally stop thc effects but if cbd is taken in correct dosage it does not do that nor will black pepper...
    basically, from what I've gathered. caryophyllene is a precursor compound that directs functioning of thc/cbd etc... the pre cursors are the volatile quick to evaporate directors of the heavier thc/cbd type compounds... but yes, to many precursors can take over ( stall) thc functioning but would need a lot of them in comparison to thc/cbd etc... just adding a little amount means augmenting instead of take over
    BTW, we are talking little amounts, this is a micro dosage thread too so it fits- yes?"
     
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  3. whereskarlo

    whereskarlo Active Member

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    Yes, I hold the Pax 2 upside down while heating. It keeps the herbs in contact with the oven instead of sitting on the oven lid which isn't heated. It works and the difference is night and day if you just have a small pinch in there.
     
  4. C No Ego

    C No Ego Well-Known Member

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    715
    have I mentioned in this thread for microdosing - degummed hemp fiber?

    if you want to micro dose with any vape use degummed hemp fiber as a filler in the herb chamber to take up space that the herb would have otherwise occupied thereby dosing with less herb... I do it all the time now and stay good and medicated with the smaller amounts...
     
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  5. vapeymcphee

    vapeymcphee Well-Known Member

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    An effective method for microdosing? So you turn it right way up to take single hit and done?
     
  6. archangelz001

    archangelz001 FIRE!!

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    I have to admit I'm not tracking your logic. In my experience CBD does not potentiate the effect of THC in any way - it moderates it greatly. When you say caryophyllene "directs functioning of THC/CBD" I really don't know what you mean. Beta-Caryophyllene is high in strains that have a spicy-peppery aroma component like many Cherry AK phenotypes - and helps to keep the high more focused and less spacy. But I'm not sure what you mean when you say it "augments" the effect of THC. Eating a mango 45 minutes before vaping, which is high in Myrcene, supposedly augments the THC high - i.e., gives it a boost.

    So, my experience, as a microdoser who used 0.05gm per vape session or less in the past, am now having to use closer to 0.1gm when I vape in order to feel the THC exactly because the 2:1 CBD/THC oil I'm taking sublingually tamps down it's effects - it doesn't augment it.

    Am I just really totally misunderstanding what you are saying?
     
  7. C No Ego

    C No Ego Well-Known Member

    Messages:
    715
    it has to do with the volatility of each compound ( vaporization charts) and how long that compound can have an active effect on receptor signalling... the precursors, like black pepper start the signalling process while thc/cbd as more heavier compounds come in after the more volatile compounds to sit at the receptor juncture... the pre-cursors are toggling receptor functioning and because of their volatile nature they do it first before the main compounds... like I mentioned too it is the amounts used that determine if you totally stop thc effects etc... with just tiny amounts the pre cursors can direct thc/cbd to last longer, they are called cannabimimetic agents
     
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  8. archangelz001

    archangelz001 FIRE!!

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    @C No Ego what is your actual experience using cannabis that is rich with CBD? Does it augment the high? Or dampen it?
     
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  9. C No Ego

    C No Ego Well-Known Member

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    715
    yeah, no experience with it... just some experience with black pepper, limonene etc... cannabimimetics.. added to thc rich strains ( black market east coast)...
     
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  10. stressed

    stressed Well-Known Member

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    sniffing black pepper is an old trick to come down a bit. i never needed it back in the day but i made a bunch of cannabis capsules and ate too much a few times. duh.

    when i realized i was fucked, i would just sit there and smell the pepper a few seconds at a time. for me at least, it works. might be in my head but whatever works eh? i hate being too high from eating pot, it's a very uncomfortable feeling.


    my pot doc was talking up CBD products. he's a huge fan. i need to buy some. i go to sleep like a champ but can't stay asleep for more than 1.5 hours. it's annoying waking up 5 or 6 times a night.
     
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  11. biohacker

    biohacker Fucking Combustion Since 2006

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    Storey of my life, and another reason i'm taking a break, so I can get back to normal healthy sleep. I usually am good for about 3-4 hours and then it's over and I feel like complete garbage all day long.

    I just picked up some 99% pure CBD isolate crystals that can be ingested or vaporized, as well as CBD tinctures. I do plan on adding CBD on a regular basis as well when I get back to vaporizing THC.
     
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  12. EverythingsHazy

    EverythingsHazy Well-Known Member

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    884
    On the topic of microdosing, do you guys who use 0.2g or less per session, notice any lasting energy loss after the buzz wears off? Also, have you taken a break for more than a week? I think until you've gone on a break for 7+ days, it's difficult to tell if you'd feel any different without Cannabis.
     
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  13. cannabis.pro

    cannabis.pro OpenCannabis Advocate with a shop at 420EDC.com Accessory Maker

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  14. biohacker

    biohacker Fucking Combustion Since 2006

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    Thanks for posting! Good article, just a couple of things I noticed:

    After writing down your scores, he says, you take the cannabis, wait 45 minutes and ask the questions again. If there's been no change in your scores and you've felt no effect, increase the dose by one gram.

    The need a better editor!!!!

    I asked how he treats heavy users who've developed a high tolerance. Sulak says they begin by abstaining for 48 hours. "That's all – that's the magic time when tolerance gets re-set."

    Although 2 days will help, that is nowhere near the amount of time needed to actually reset your tolerance to zero. At 2 days I don't even think tolerance would be at half mast for many daily users. From personal experience, it's more like 1-2 weeks, and if you really want to reset it, wait until you're completely clean, about a month or so. Then again, I could be completely wrong - since Dr Sulak uses "resensitization" by increasing receptors with micro doses.

    Why do you guys think? What would reset tolerance more? Abstaining completely, or abstaining for a couple of days and then micro to increase receptor density? Interesting shit!
     
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  15. cannabis.pro

    cannabis.pro OpenCannabis Advocate with a shop at 420EDC.com Accessory Maker

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    Don't we all.

    Vape a session today. Are you still feeling the effects in 48 hours? No, do you still have THC in your system, sure it is in your fat and in your blood and it gets disposed of in urine. I don't see why one needs to wait for it all to be out of the blood/body to figure out what a workable microdose is. Medical marijuana users don't use the plant once a month and wait until it is all out of the system before using it again.
     
  16. lazylathe

    lazylathe Almost there...

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  17. biohacker

    biohacker Fucking Combustion Since 2006

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    :rofl:

    You missed the point. And all my questions weren't intended to be sarcastic, they are very genuine questions i'm fielding to members here.

    And gosh lighten up man! :peace:
     
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  18. cannabis.pro

    cannabis.pro OpenCannabis Advocate with a shop at 420EDC.com Accessory Maker

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    @biohacker apologize for the lack of tone and vocal diction in my text. I didn't detect sarcasm in your post. I was just trying to clarify and address your questions with whatever rolled off my fingers and out of my brain without going all pharmacological about it.
     
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  19. biohacker

    biohacker Fucking Combustion Since 2006

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    All good bro, it's the nature of the interwebz! :tup:

    I do appreciate your points and agree, but there was alot of comedy with the editor stuff :lol: When you said don't we all, because I said "the" instead of "they".... that cracked me up, but then you put the . instead of ? and that really was gold! :lol:

    I'm on a 3 week and going break myself, but realize that just 48 hours makes a massive difference, and realize that medical patients sometimes can't go more than 48 hours. I can, but i'm going through hell, but also have the luxury of not having to work at this time, so I accept the agony. Sometimes you need a TOTAL RESET, in order to get to your old self and figure out the chicken or the egg conundrum.

    Cheers man! :peace:
     
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  20. cannabis.pro

    cannabis.pro OpenCannabis Advocate with a shop at 420EDC.com Accessory Maker

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    @biohacker Your a stronger person than I on a hiatus like that. Are you going to try this type of regimen to find your tolerance when you decide to partake again? I'd be curious to try something like this if I could find the proper tincture to try.
     
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  21. biohacker

    biohacker Fucking Combustion Since 2006

    Messages:
    5,333
    It's the only way to sustain medicating for me, as when I hit tolerance I get all sorts of bad side effects. It's either micro dosing or not using cannabis at all and having to resort to pharmaceuticals for my conditions (and that's NOT an option as i'm way too health oriented). It does suck, but mostly because of the sleeping problems, otherwise I don't crave, my mood is stable, etc. but constantly feeling like garbage from 1/2 nights of sleep takes its toll.

    I've actually already done this regimen before, after a 2 week break and it's true - .05g felt more powerful than when I vaped 1g in a session! I'm a pretty extreme case though, using heavy for the past decade, high grade hydro at 2g/day.

    I have all my tinctures ready to go as well, so might start there instead of vaping...I have thc, cbd, and blends of both, presently experimenting with the cbd.

    Micro dosing is the new macro dosing! :rofl:
     
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  22. Tommy10

    Tommy10 Well-Known Member

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    Click to play YouTube Video
     
  23. stressed

    stressed Well-Known Member

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    i mico dose and feel fine after. no come down, tired feeling.

    i've been smoking and vaping for 46 years and i've never taken a T break. i always have a few genetics and switch them out everyday if not a couple times during a day. if i'm not getting as high on a genetic, i'll start with even smaller doses for a couple days and i'm right back to getting a lovely buzz with .05 of bud.
     
  24. nomadicsoul34

    nomadicsoul34 Well-Known Member

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    Im experimenting to see just how little i can use a still get a nice buzz. Earlier tonight i got a lovely high from less than 0.01
     
  25. archangelz001

    archangelz001 FIRE!!

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    0.01gm?? Man, you are bordering on placebo effect. I thought I was a microdoser at .05 to .1 ...... sheesh!:brow:
     

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