This is very hard to sort out. People need to try it on themselves or the patient, big variation. The cannabiscure article is full of misstatements. And they debate the topic of rectal absorption with some people referencing THC and others THC hemi-succinate. Apples and oranges. More guesswork than anything, still.
THC hemi-succinate is not just THC that's "processed" with vitamin E etc, nor is an "additive" used. It's an altogether different compound, made in a chemistry lab. Different methods and yields for the reactions have been
documented. This isn't very difficult chemistry, but it's lab level chemistry. Yet if
Homo Harleyus has discovered simple ways to synthesize meth from beer cans and Sudafed tablets, there's always hope for kitchen chemists. Possible advantages of THC hemi-succinate over THC are just part of a
very technical ongoing search for ideal formulations.
There's a lack of good human data on rectal absorption of THC-A, THC and others. And making effective suppositories isn't all that easy. I suspect that lack of psychoactive effect shows that it's not being absorbed. All this talk of "first it goes here" is implausible, because the system functions at equilibrium. As to activity against cancer cells,
different cannabinoids have been most active against different cells. Applying cannabis to cancer patients nowadays is largely a crap-shoot (forgive the pun). Full spectrum extracts are most often used, in the hope that the most active cannabinoids for that particular cancer will be
in there too.
Oils rich in THC have shown excellent topical activity on some skin cancers. With lower colon and rectal cancers it's plausible that suppositories can act topically on the tumor. Eating the oil lets the upper intestine do its job in absorbing and distributing fat soluble cannabinoids. Rick Simpson style saturation bombing with oral oil is still probably the best bet overall.
As to the incapacitating effect of doses escalating towards what some would consider
apocalyptic, like 800 mg THC/day, it's mostly exaggerated. Humans adapt. Using a sedating Indica-leaning strain is important. After a couple of weeks someone's son was driving and going fishing.
Our stunning ignorance 40 years after the initial discoveries is a shameful testimonial to the effectiveness of moralistic prohibition in castrating inquiry, even on a topic as important to EVERYONE as cancer therapy.
