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Immune system vs. cannabis

Discussion in 'Medical Discussion' started by -dab8-, Jan 4, 2019.

?

Have you found cannabis use to increase illness frequency?

  1. Yes, but it’s worth it.

  2. No, just the opposite, I never get sick since I started using.

  3. I’m not sure yet.

Results are only viewable after voting.
  1. Sick Vape

    Sick Vape Solar Dabs

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    144
    You could have a point.
    limonene, 1,8-cineol, b-caryophyllene, b-pinene and others are known to be antiviral. THC and CBD also and probably other cannabinoids too.

    @C No Ego I agree. Well, aside that CBD can have pretty immediate effects too. But I think I get what you are saying.

    @ataxian :peace: :love:&:leaf:
     
    Last edited: Jan 10, 2019
    Alexis, Madri-Gal, C No Ego and 2 others like this.
  2. -dab8-

    -dab8- Dyna-saur

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    Location:
    East coast
    Please don’t, all opinions and insights welcome here. I appreciate your input.
     
  3. ataxian

    ataxian PALE BLUE DOT

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    I know I sound like a GRUMPY OLD GRANDPA!
    CANNABIS is safer than MILK?
    Why is it fronded on?
    HYPOCRISY!!
     
  4. hibeam

    hibeam alpha +

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    Location:
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    Haha, I think some people here do brag about microdosing...and it does deserve an award if one used to be a megadoser :D But ...

    Milk surely does me way more harm! Cannabis may in fact protect one a bit from it?
     
    Alexis, Madri-Gal, Sick Vape and 3 others like this.
  5. C No Ego

    C No Ego Well-Known Member

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    1,517
    yeah, it is economy based and health based and knowledge based somewhat... check out Dustin Sulak and his micro dose info on how initiating those enzymatic amides and epoxides ( FAAH / PPAR / TRPV1 / CYP450) via a micro dose of phytocannabinloid works. also, it activates the Arachadonic acid cascade , which is basically cannabinoid signalling via lipid metabolism and bio-active enzymes
     
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  6. hibeam

    hibeam alpha +

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    Location:
    Brave New World
    Alexis, Sick Vape, -dab8- and 2 others like this.
  7. ataxian

    ataxian PALE BLUE DOT

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    U will live forever like a celestial North KOREA!
    I like CANNABIS.
    Da more da better!

    It’s my POV!

    @hibeam I’m GF as well!
     
    Last edited: Jan 12, 2019
  8. Sick Vape

    Sick Vape Solar Dabs

    Messages:
    144
    Everything has its place.
    Not everyone always can tolerate big doses. Not everyone always profits of microdosing (well maybe everyone would if the dose was apropriately chosen).
    Microdosing works incredibly good for some things and people at certain times with certain strains.
    Megadosing too.

    I think there is no general rule of which one is better.
    There is so much more happening than just big dose of cannabinoids or small dose of cannabinoids!
     
    Alexis, C No Ego, ataxian and 4 others like this.
  9. analytika

    analytika Well-Known Member

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    Location:
    San Francisco, California
    It's what economists call a multivariate preference function. How do you balance your preference for: (I) how high, and (II) how often.

    Microdosing isn't always about getting less high, it can be about not getting very high too often.

    Microdosing isn't always about getting high less often, it can be about getting less high quite often.

    Now, go optimize! It's about tolerance and preferences.

    Side effects such as impact on the immune system don't necessarily follow the same toleramce rules.

    If tolerance is less of a factor on immune system side effects, a microdoser may experience fewer immune system effects, for the same high.
     
    Last edited: Jan 12, 2019
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  10. Madri-Gal

    Madri-Gal Child Of The Revolution

    Messages:
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    Location:
    Livin' in the 707
     
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  11. hibeam

    hibeam alpha +

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    Could it simply be some users have such damaged eCB systems that the more cannabinoids the better to a much greater extent? While, others with mediocre to good eCB systems can accidentally throw theirs off by increased tolerance? I like the idea of protecting immunity by microdosing: some may really need to step this carefully.
     
    C No Ego, Squiby, Madri-Gal and 3 others like this.
  12. Sick Vape

    Sick Vape Solar Dabs

    Messages:
    144
    Yes. If it is about getting high, it's about tolerance, i think.
    I only can build a tolerance for the high effect it seems. The effect on pain for example, especially severe pain stays the same.
    I need the same amount even after a tolerance break. I just get very high then.
    I cannot directly tell the impact on the immune system positive or negative, so it is impossible for me to detect tolerance buildup there.

    I think we are at the beginning of trying to get to know the eCB system. It is huge and interferes everywhere. The more we research the more questions arise.
    For the patients there is no time for waiting for the research. They need to be able try as many options as possible to see what helps them most.
     
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  13. ataxian

    ataxian PALE BLUE DOT

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    Location:
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    I have late on set ATAXIA (SCA) if you can cure it my hats off 2 U!
    MICRO is 4 some.

    I like CANNABIS 4 managing my needs?
    Sorry this not the right place 2-B!
    Carry on my friends!
     
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  14. C No Ego

    C No Ego Well-Known Member

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    because the extracellular / exogenous second messenger phytocannabinoids act down stream they serve as down regulators/ modulators... if to much are present they then up regulate that ell function.
    people mega dosing would be 360 degree regulating that function LOL ... Spiral / implosion regulation

    @hibeam thanks for the link, I have gotten lost on that site a few times... to much suppressed info not enough time
     
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  15. Sick Vape

    Sick Vape Solar Dabs

    Messages:
    144
    I am no doctor, @ataxian. I wish I could cure you or help you. It seems you have found a way with cannabis to feel better. Thats good, no?
    I am just a little dust on a pale blue dot.

    @C No Ego that 360 degree regulating would only work on cyclic cell functions? (haha, officially marked as joke)
     
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  16. Alex3oe

    Alex3oe Well-Known Member

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    smoking tobacco on a regular basis is not even very bad for the immune system, it makes it easier for bacteria or viruses to enter your system too
     
  17. ataxian

    ataxian PALE BLUE DOT

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    I am benefiting from CANNABIS.
    I will not bother you fine members.
    Like I said I don’t belong here!
     
  18. hibeam

    hibeam alpha +

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    Location:
    Brave New World
    Don't get too frustrated with us yet! The patients out there who neeeeeeeeeeeeeeeeeeeeeeeed
    megadoses like you also need to raise their voices until they are heard. Our docs down here still blink at a gram per day recommendation, typically maxing it around 200mg THC. I go through around 40mg/40mg thc/cbd a day for my prob but my first doc would not let me have over 20mg.
     
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  19. C No Ego

    C No Ego Well-Known Member

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    1,517
    RSO oil and cancer patients are using 1000 mg to 3000 mg daily activated 80 to 90% oil . if tolerance is of issue then a rectal suppository is used to offset tolerance to the compounds
     
  20. ataxian

    ataxian PALE BLUE DOT

    Messages:
    12,057
    Location:
    Pacific Ocean
    Where did you receive your PHD?
     
  21. C No Ego

    C No Ego Well-Known Member

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    1,517
    right here man @ FC
     
  22. Sick Vape

    Sick Vape Solar Dabs

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    I don't buy that suppositories don't get you high.
    Has anybody really tried?


    Edit: Sorry @C No Ego i am often questioning your posts lately. It has nothing to do with you. I like the posts
     
    Last edited: Jan 15, 2019 at 6:04 AM
    ataxian, C No Ego and -dab8- like this.
  23. looney2nz

    looney2nz Research Geek, Mad Scientist

    Messages:
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    Location:
    So Cal

    I believe C No Ego is correct here.

    this site/page is interesting: https://cannabiscure.info/cannabis-suppositories/

    Originally conceived of and patented by the Israeli 'Father of Cannabis', with an accompanying paper in the Lancet in the '90s.

    The absorption rate is supposed to be quite high (predicated on the carrier lipid), but it bypasses the liver, which is where delta-9 gets converted to 11-Hydroxy-Δ9-THC, this metabolite of delta-9 THC is the major psychoactive portion that gets you high. (it's also the PRECISE metabolite they are testing for when you are urine tested!)

    So bypassing the liver should allow higher plasma and tissue levels without being a blithering idiot :)

    @fernand this link is interesting! how involved to convert into an acetate?

    if any of you are around the burn areas, stay safe! The 1st day of actual rain in CA and now begins the OTHER downside of these fires. More powerful storms lined up until thursday night :(
     
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  24. Sick Vape

    Sick Vape Solar Dabs

    Messages:
    144
    Thank you very much for this info. It would be like inhaling cannabis without inhaling and the head high. Should be perfect for me as I really don't like the effect of eaten cannabis and my lungs would often prefer air only. And my short time memory would like to recover too I guess.
    I will have to try (still don't buy it, i stubborn head :bang: in this case).
    Is there anything known what happens with thc-a when administered in suppositories?


    Edit:
    Sadly they use a THC-hemisuccinate in the study, which I cannot easily make at home.
    THC in fat does not get absorbed well rectally according to them.

    And yes in europe many medicaments get sold as suppositories too, no taboo here. Just wash your hands, lol. And don't medicate in public.
     
    Last edited: Jan 15, 2019 at 8:33 AM
  25. C No Ego

    C No Ego Well-Known Member

    Messages:
    1,517
    yeah, the reports I've found coconut oil is used in gel cap with the cannabis oil mixed into it @ volume. then the caps get put in freezer. they are frozen for rectal insertion... you have much more absorption capability down there without your digestive juices/ bile acids getting in the way and also less of that 11 hydroxy conversion that makes people see angels. for women a vaginal suppository does the same thing ETC....
    I found this info out looking into RSO and cancer... people having to much psycho activity from ingestion in the mouth while trying to work up to one gram of activated oil daily... the same people found they could go up to three grams in the rectal suppository route with way less to no psychoactivity...
    Edit - go to Grasscity.com and look up the hash oil threads where RSO is made into caps and such... too - Bad kitty smiles world summit https://duckduckgo.com/?q=Bad+kitty+smiles+world+summit&t=ffcm&atb=v62-6__&ia=videos

    edit 2- explained - Bile acids and cannabinoids https://duckduckgo.com/?q=Bile+acids+and+cannabinoids&t=ffcm&atb=v62-6__&ia=web
     
    Last edited: Jan 15, 2019 at 11:03 AM
    -dab8-, looney2nz and ataxian like this.

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