Thanks, now I have enough readings for the long weekend! I am particularly interested in the above article you linked about how spices can compensate for high glycemic diets: (about half-way into it)
"Spices are typically rich in essential oils and terpenes, thus providing a source of potential lipid modulators of the endogenous lipid systems, including the ECS, TRP channels (TRPV1 and TRPA1), the PPARs and the overall eicosanoid system (see also Russo,
2016). Just like salt increases the palatability of food, certain hot or flavoured spices can do the same. However, there are many spices in agriculturist diets that exert pharmacological effects. For instance, phenylpropanoids from ginger (
Zingiber officinale L.) have been shown to pleiotropically interfere with the arachidonate signalling system by targeting COX-2 (van Breemen
et al.,
2011) and PLA2 (Nievergelt
et al.,
2011), leading to potent anti-inflammatory effects by disrupting IL-1β expression (Nievergelt
et al.,
2011). Numerous plant volatiles among spices modulate ion channels (Maffei
et al.,
2011), such as TRPV1 that signals to the ECS. NAEs like palmitoylethanolamide (PEA) are very abundant in flowering plants (Gachet
et al.,
2017), which constitute a major source of food. Given the emerging pharmacology of PEA (Petrosino and Di Marzo,
2017), it will be interesting to assess the biological contribution and significance of NAEs from diet. Overall, this dietary adaptation to eating green leafy vegetables and spices rich in essential oils and NAEs may not be a coincidence but a biological function to counteract metabolic stress induced by the excessive carbohydrate intake."
I have more than a few metabolic challenges because I have inherited genetic flaws that work against each other. This article explains my biggest problems, which are shared by people on the AUTISM spectrum:
http://autismcoach.com/the-glutathione-sulfation-methylation-pathway/
The toxins my system builds up because of the above discussed glutathione-sulfation-methylation pathway breakdown are my main MIGRAINE triggers. So now I am learning WHY whole flower micro-dose vaping of whole cannabis flower or trim throughout the day improves my digestion and metabolism to the point of helping me prevent daily migraine attacks.
I still have to stay away from certain foods completely, namely anything high in tyrosine, tyramine, taurine, glutamine, and other amines (histamine) that come from the decay of protein or in the natural fermentation process.
But when I use cannabis, the digestive enzymes and minerals I take WORK BETTER and I can get away with eating a little red meat I need for the carnitine now and then. I tolerate some high histamine foods much better when I use mmj. This is key because in order to avoid daily migraine my diet is extremely and somewhat dangerously limited!
It's a very long story and I hope at least that my mentioning migraine and genetic profiles and metabolic disorders will inspire other migraine sufferers to get to the root of their problems especially when the typical migraine abortive drugs have side effects worse than the original migraine attack.
The doc recommended dose of CBD is still giving me headaches, but I am tolerating barely a drop of the oil if I double up on the high THC flower vaped at low temperatures. And my overall sense of the mmj situation in FL unfortunately inhibits me from even trying to talk about this with my doc when I go back for adjusting my rec. I don't think patient needs have ANYTHING to do with what gets rec'd, but I will report back.
