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Cannabis' Effects on Concussive Brain Injury

Discussion in 'Medical Discussion' started by EverythingsHazy, Sep 3, 2017.

  1. EverythingsHazy

    EverythingsHazy Well-Known Member

    Messages:
    969
    This is a thread for the discussion of the effects of Cannabis on brain damage caused by concussive blows.

    This kind of damage is possible to get when competing in full contact sports like boxing, MMA, football, rugby, etc., and Cannabis is being researched for its potential to prevent/mitigate/heal it.

    If anyone has any good links to articles about its effects this kind of brain trauma, share them here.

    Here is an open letter from a Harvard psychiatrist to the commissioner of the NFL:
     
    Last edited: Sep 3, 2017
    Silver420Surfer and grokit like this.
  2. C No Ego

    C No Ego Well-Known Member

    Messages:
    1,029
    I'll start with these links, not exactly concussion related but explains some of the process. I was going to post in another thread but will here as it's pertinent..

    here is a few articles... I'll find a few that get into more detail... the Alzheimer studies are leading the way it seems for neuro type studies


    The Endocannabinoid System: A Putative Role in Neurodegenerative Diseases

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070159/

    Cannabinoids: New Promising Agents in the Treatment of Neurological Diseases
    http://www.mdpi.com/1420-3049/19/11/18781

    N-stearoyltyrosine protects primary cortical neurons against Aβ(1–40)-induced injury through inhibiting endocannabinoid degradation

    http://www.sciencedirect.com/science/article/pii/S0024320515000521
     
  3. grokit

    grokit well-worn member

    Messages:
    11,799
    Location:
    the north
    @C No Ego
    Do you know if either of those latter two were one of the studies that ncbi is alluding to when they said,

    "Several studies have demonstrated neuroprotective effects of cannabinoids."?

    edit: This article from leafly includes sections on
    • How Cannabis Can Slow Traumatic Brain Injury Damage
    • Can Cannabis Help People Currently Suffering From TBI?
    • CBD Can Be Remarkably Effective for TBI
    It also mentions these three studies:

    "Effect of Marijuana Use on Outcomes in Traumatic Brain Injury" (UCLA Medical Center, 2014):

    In a three-year retrospective review of 446 separate cases of similarly injured patients, researchers found traumatic brain injury (TBI) patients who had a history of cannabis consumption possessed increased survival rates compared to non-consumers (97.6 percent survived surgery, versus 88.5% of those who didn’t consume cannabis).

    "[O]ur data suggest an important link between the presence of a positive THC screen and improved survival after TBI," the researchers concluded. "With continued research, more information will be uncovered regarding the therapeutic potential of THC, and further therapeutic interventions may be established."
    “Endocannabinoids and Traumatic Brain Injury” (Mechoulam, 2007):

    This Israeli study points to research that demonstrates:

    “…the [endocannabinoid] system…has the ability to [positively] affect the functional outcome after TBI by a variety of mechanisms.”

    “The Therapeutic Potential of the Cannabinoids in Neuroprotection” (Grundy RI, 2002):

    This review shows that in experimental models:

    “…various cannabinoids rescue dying neurons in experimental forms of acute neuronal injury, such as cerebral ischaemia and traumatic brain injury.”

    :cool:This article also looks pretty good imho:
    Traumatic Brain Injuries – Medical Marijuana Research Overview

    :bang::ko:
     
    Last edited: Sep 3, 2017
    C No Ego and Silver420Surfer like this.
  4. C No Ego

    C No Ego Well-Known Member

    Messages:
    1,029
    A few more info related articles... First, would like to point out the importance of FAAH .. FAAH is the signalling mediator of the entourage effect from multiple types of cannabinoids that interact with receptor channels simultaneously
    FAAH
    http://www.bionity.com/en/encyclopedia/FAAH.html

    ^ This stalling/slowing/mediating function of ECS signalling is of most importance for an entourage continuum of multiple functioning cannabinoids exerting bio-activity @ the cb juncture of the pain receptor.. FAAH basically is- cbd slowing down thc effects @ cb-1 receptor...
    cbd acts as an antagonist molecule @ cb2 receptor and thc acts as an agonist molecule @ cb1 receptor... without cbd antagonist ability thc runs rampant possibly over signalling ( paranoia/ Anxiety etc..) cbd slows down over signalling of thc.

    This article shows more of the process V
    Beta-caryophyllene is a dietary cannabinoid

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2449371/


    Here is the secondary metabolite signalling function explained....
    http://www.bionity.com/en/encyclopedia/Lipid_signaling.html


    other older studies
    Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/

    Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning
    http://www.pnas.org/content/105/25/8760.short

    The endocannabinoid system in normal and pathological brain ageing
    Andras Bilkei-Gorzo
    http://rstb.royalsocietypublishing.org/content/367/1607/3326

    The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis
    http://www.jbc.org/content/282/33/23892.full

    Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230631/#pone.0028668-Prins1

    The effect of cannabichromene on adult neural stem/progenitor cells.
    https://www.ncbi.nlm.nih.gov/pubmed/23941747

    A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/

    Long-term behavioral and biochemical effects of an ultra-low dose of Δ9-tetrahydrocannabinol (THC): neuroprotection and ERK signaling.
    https://www.ncbi.nlm.nih.gov/pubmed/22821081


    @grokit I honestly do not know... I'm sure all these new articles just add to the confusion puzzle... Peace
     

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