Prescription Drugs CAN Negatively Affect the High...

lwien

Well-Known Member
So here's the deal.

About a year ago, every once in awhile, my gums would just be burning. I would also be salivating a lot. Dentist didn't have a clue as to what it was. Didn't happen all the time, maybe about once or twice a week.
I then noticed that I was really putting a lot of spices on my food. Lots of garlic and crushed red peppers. I chalked that off to just growing older and that typically, ones taste buds don't work as well when one ages so I needed to spice up my food.

Then, about a month ago, every once in awhile, I'd get really hoarse, like I was loosing my voice. I was also constantly clearing my throat.............that old frog in your throat thing, but what was REALLY bad was the feeling that I had a clump of mucous stuck to the back of my throat when in fact, there was nothing there. I could deal with that feeling during the day, but it really fucked with my head when trying to go to sleep. Kinda felt like you were drowning or chocking when you really weren't. Could breath fine. Just that weird feeling in the back of your throat. Kept me up at night.

Anyway, initially thought it may be allergies, so I tried Claritin, Mucinex and Nasacort. Nothing worked.

Then I went to the doc who diagnosed me with laryngopharyngeal reflux (LPR), also known as silent GERD. I never heard of that before. I thought that GERD was always associated with heartburn, but I found out that this is not always the case. With regular GERD, stomach acid irritates the esophagus which results in heartburn. With LPR, the amount of acid coming up is much smaller so it's not felt as heartburn but with LPR, it travels up into your throat and larynx and over time, inflames them which causes the symptoms that I had.

She prescribed me a 45 day run of Omeprazole, which is the generic form of Prilosec, a PPI that inhibits acid production. I'm 3 weeks in and it's working great. Symptoms not gone completely but 80% improved. My taste buds are back. I can taste small amounts of black pepper that I haven't tasted in years, so obviously, this has been a long term issue. But it's a bandaid but I've made some lifestyle changes that hopefully, will address the issue after my script runs out.

So back to the title of this thread. What I have noticed, and it's very real, is that Omeprazole (Prilosec) negates the high I get from vapor in a very big way. I don't get nearly as stoned as I did before I started taking this drug. It would be nice if this was listed as a side effect, but I'm not gonna hold my breath for that to happen.:brow:

Has anyone else had this happen, either with this drug or any others in regards to weakening the MJ high?
 

Vicki

Herbal Alchemist
I am sorry you have been having problems. I don't think I've experienced anything like this, but I need to think on it a little more. Interesting topic, and I'm looking forward to hearing what others have to say about this subject.
 

lwien

Well-Known Member
I'm on Omeprazole 40mg ,and have been for a a few years and don't notice any difference in how high i get while vaping :hmm:

Hmmm............must be kinda like edibles in that we all react a bit differently, and sometimes, a lot differently.

I am sorry you have been having problems.

Thanks for the thoughts, Vicki, but while this is an issue for me, in the whole scheme of things, especially when one considers what others have been dealing with here, what I have is VERY minor. I just hope that once the symptoms are gone that I can keep them at bay without having to go back on this script again.
 
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elvenflow

Well-Known Member
Proton pump inhibitors have a significant effect on the HPA axis (which is what gives many folks the munchies)
http://www.ncbi.nlm.nih.gov/pubmed/16524691

"Single administration of lansoprazole caused significant (P<0.05) increase of ACTH-IS at 60 and 120-180 min, and cortisol at 180-240 min after administration, compared with placebo group. Rabeprazole also caused significant increase of ACTH-IS at 120 min and cortisol at 240-360 min, compared with placebo group. Omeprazole had no effect on plasma ACTH-IS and cortisol levels. Lansoprazole and rabeprazole increased plasma ACTH-IS and cortisol levels. Therefore, we hypothesized that the medicines might activate the HPA axis, and have effect to promote feeding."


Prevacid has often been proposed for use in so-called "cannabis withdrawal syndrome" since it increases appetite, and, as you have noticed, reduces the effects of cannabis. Keep this to yourself, though, it could destroy the cannabis rehab industry if people knew that cheap over the counter antacids could result in cessation of cannabis usage without need to resort to expensive inpatient stays.;)
 

lwien

Well-Known Member
To you guys that are taking Omeprazole long term, are you also taking vitamin and mineral supplements? I've heard that the reduction in stomach acid can have a real impact on B12, folic acid and magnesium levels.
 

t-dub

Vapor Sloth
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t-dub

Vapor Sloth
Ambien turns your brain off. It lowers all activity as far as I can tell, and with that comes the sensations of being high. Ambien seems to dull everything down and just kinda screws the high you worked so hard to achieve.
 

Vicki

Herbal Alchemist
Ambien turns your brain off. It lowers all activity as far as I can tell, and with that comes the sensations of being high. Ambien seems to dull everything down and just kinda screws the high you worked so hard to achieve.

Thank you. I am getting practically no restful sleep, and I see my GP beginning of February. I know she will suggest Ambien, but I'm asking her for Restoril. I hate RX drugs, but if I have to take them, I prefer older ones.
 

Eschient

Giga-Dweebess
To you guys that are taking Omeprazole long term, are you also taking vitamin and mineral supplements? I've heard that the reduction in stomach acid can have a real impact on B12, folic acid and magnesium levels.

Just mentioning this because I talked to my Dr. just last week about starting B12 to help my depression. She told me that I should look for sub-lingual B12 because the gut doesn't absorb the pills as well. B12 supplements need stomach acid to break down and absorb in all sorts of complicated ways that I don't understand without coffee, but brains says eyes see articles that mention PPIs like Prilosec can further inhibit absorption in the digestive tract. So, you might look for a sub-lingual form of some of those supplements. I know there's a whole slew of B12 lozenges and drops available.
 

Melting Pot

Sick & Twisted
I take omezaprole,citalapram,digoxin,attenolol,prodaxia,cartia,tramadol,norpace,prevastatin.I think that's all of them and something is definitely fucking with my high Or my tolerance is going through the roof!!!
 

Vicki

Herbal Alchemist
I take omezaprole,citalapram,digoxin,attenolol,prodaxia,cartia,tramadol,norpace,prevastatin.I think that's all of them and something is definitely fucking with my high Or my tolerance is going through the roof!!!

I have taken Pravastatin for years, and it has never messed with my high. I also took Tramadol for a while too, and it never affected it either. It's probably not the Celexa because I take an SSRI as well, (Paxil), and it doesn't mess with the cannabis. They are both of different chemical makeup's, so I could be wrong. I know a lot of people who take Prilosec and use cannabis with no problem, but then people are also different, and how they react to medications vary.
 

lwien

Well-Known Member
Regarding generic omezaprole, has anyone noticed that the capsules are not fully packed. I just noticed that when I was taking one, I could hear the time release grains shaking about inside. Seems that they are only 3/4 filled. Kind of threw me in that it's always been my experience that drug capsules are always packed to the brim.
 
lwien,

VaporsVaporizer

On the Stoop
Regarding generic omezaprole, has anyone noticed that the capsules are not fully packed. I just noticed that when I was taking one, I could hear the time release grains shaking about inside. Seems that they are only 3/4 filled. Kind of threw me in that it's always been my experience that drug capsules are always packed to the brim.
Not uncommon to have some space inside a capsule, they fill the bottom with the required dose and then stick the cap on. I've always been able to hear the grains inside a capsule . It depends on the size of the capsule how much you hear them . Open one up, you'll see that the bottom is almost filled to the brim.
 

Snappo

Caveat Emptor - "A Billion People Can Be Wrong!"
Accessory Maker
Not sure, but I would think that PPI's (Prevacid, Prilosec, Nexium, etc.) could impede absorption or breakdown (reduced acids) of ingestables to inlude oral tictures, oral oils, etc., and therefor impede or somehow alter their effects, though this has not been my experience. :2c::2c:
 

Melting Pot

Sick & Twisted
I made some AVB butter and still seem to be enjoying that and I regularly have AVB milkshakes and still loving the effects from them.:tup:

I think I'm just building up my tolorance to much edables,concentrates and vaping.maybe need to take a break.:lmao:
 
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Magic9

Plant Enthusiast
Some SSRIs and/or AAPs will interact, and keep you from getting where you need to be.

Painkillers (synthetic opiods, tramadol, codones, etc.,) have a very positive interaction for me. They play very nicely together, and seem to intensify each other.

Just my experience.
 
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Magic9

Plant Enthusiast
@Magic9

"Some" SSRI's? Do you know which ones? Paxil? Prozac?

I only have limited experience with Paxil (essentially same as prozac). The short time I was on it, I was also on a sedative AAP. It's hard for me to say exactly which one caused it, could of just been the combo, or even just my own mind state at that particular time.

But...I wouldn't really feel the cannabis effects. I'd get sleepy (could of been AAP), and relax a little, but not much else. It wasn't bad, just felt like it was blocking me from getting the effects I knew I should of felt. I remember doing some research when it was prescribed, and ran into very few stories of bad interactions, so I'm sure in most cases it is unnoticeable. Just my personal experience.

Research wise, other than having higher levels of metabolized THC in your system, and possibly higher levels of the SSRI, due to the body excreting the SSRI before the THC, there does not seem to be much risk.

The cannabinoid receptors are not serotonin mediated. Since low doses have been found to increase serotonin, I'm sure there are cases where it has helped the SSRI do its job.
 
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