Up-regulate instead of Down-regulation

I have read around this site and I have come to the conclusion that if you you a small amount (.025) of the herb you could potentially up-regulate the cannabinoid receptors. Since down-regulation occurs when more is used then necessary could you use a smaller amount than needed and have the body adjust over time by increasing the amount of receptors? Following this logic couldn't my body adjust to that and get used to using such a small amount to get very stoned instead of having to use more? I would love any feedback as I don't really know if this could work.

Welcome !
It does works in a way, also changing the nature of the effects you feel

I didn't like how strong it gets the head when you use micro amounts, its nice to have a good tolerance to avoid bad experiences likes over medication or tension drops.

Roger D said:

Welcome !
It does works in a way, also changing the nature of the effects you feel

I didn't like how strong it gets the head when you use micro amounts, its nice to have a good tolerance to avoid bad experiences likes over medication or tension drops.

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Are you saying that it is actually possible to get your tolerance that low again? I would love to have it like that again

Roger D said:

Welcome !
It does works in a way, also changing the nature of the effects you feel

I didn't like how strong it gets the head when you use micro amounts, its nice to have a good tolerance to avoid bad experiences likes over medication or tension drops.

Click to expand...

Thank you I really like this site but I couldn't let myself officially join till I got my solo. So it does work? Can you explain a bit further on what the effects were? I'm guessing you mean that it turned into some kind of super sativa experience with no body high or something along the lines of that.

If it works that way, then that's why lwien has such a low tolerance.

persontothe said:

I have read around this site and I have come to the conclusion that if you you a small amount (.025) of the herb you could potentially up-regulate the cannabinoid receptors. Since down-regulation occurs when more is used then necessary could you use a smaller amount than needed and have the body adjust over time by increasing the amount of receptors? Following this logic couldn't my body adjust to that and get used to using such a small amount to get very stoned instead of having to use more? I would love any feedback as I don't really know if this could work.

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I've found less is more if you give your system time to adapt - more high than medicated. This can be true in terms of dosage and frequency.

But if you clean up and adapt to less dosage, and then suddenly ramp it up... well, yes you can blow your head clean off (in a good way hopefully). Best way I think is cold turkey for a week and then reintroduce small amounts - that way you get over the jonesing hump quick and clean, and can feel out your willingness to get way up there.

A friend of mine is a weekend warrior exclusively and I'll call him and he can barely speak sometimes!


Edit: I wonder if there's a type of Godwin's Law in stoner forums about posting Terence McKenna material

Okay I can see that working. I am going to try this out. I vaporize every day though I wonder if that gives my body enough time to adapt or would the receptors kind of just wear out.

persontothe said:

Okay I can see that working. I am going to try this out. I vaporize every day though I wonder if that gives my body enough time to adapt or would the receptors kind of just wear out.

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Try a few days off and see! Should be a fun experiment as long as not too hard to layoff. I think it will freshen up those receptors.

lauz said:

Are you saying that it is actually possible to get your tolerance that low again?

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persontothe said:

So it does work?

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Yes

You don't even have to T break, just get a scale and scale everything down progressively

persontothe said:

Can you explain a bit further on what the effects were? I'm guessing you mean that it turned into some kind of super sativa experience with no body high or something along the lines of that.

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It can come so strong you feel tempted crawling on the floor. You experience another gravity, everything weights a ton. When you sit up your head spins and you see black (tension drop).

I don't like overwhelming experiences that much, I prefer a steady medication and I like being able to handle the product.

Factors : Grams per load / Time per session / Temperatures / How you spread it through the day, week, month / Strain / Material

satyrday said:

Edit: I wonder if there's a type of Godwin's Law in stoner forums about posting Terence McKenna material

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Not a chance in FC. I mean, what are we...a bunch of nazis?

Oh...wait... I just did it, didn't I? D'oh!

Vapinghole said:

Not a chance in FC. I mean, what are we...a bunch of nazis?

Oh...wait... I just did it, didn't I? D'oh!

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Just ask yourself..... "Self what would Hitler do ? "

Sorry OP for off topic post . Hope I Didn't Kill this Thread .

In reply to OP,

I don't know anything about up or down regulation of cannabinoid receptors but I do know that when I modified my DBV to accomodate small bowls my use and tolerance decreased fairly dramatically.

Just switching from smoking to vaping with the standard DBV whip I immediately decreased my consumption from about 3.5g/day to about 1.5g/day.

Then, after using an 18mm/14mm gg reducer, paired with a 14mm/14mm m/m gg adapter as the wand my consumption has decreased to .6g/day (5 - 1/8ths in last 29 days). My normal bowls are from about .025g to .033g.

In less than 3 months I went from an eighth a day to an eighth every 6 days and I'm not doing this to save money. I am fortunate to always have free cannabis. At this point I could vape 2 grams/day and make it till trim season, but .6g satisfies me. This will allow me to give a couple ounces away to friends in need. I love to give away weed and will be able to thanks to my DBV.

I attribute my greatly lowered tolerance to feeling more satisfied with less. The clear headed, more euphoric effects of vaping vs smoking naturally and organically led to my lowered usage and tolerance.

Roger D said:

Yes

You don't even have to T break, just get a scale and scale everything down progressively



It can come so strong you feel tempted crawling on the floor. You experience another gravity, everything weights a ton. When you sit up your head spins and you see black (tension drop).

I don't like overwhelming experiences that much, I prefer a steady medication and I like being able to handle the product.

Factors : Grams per load / Time per session / Temperatures / How you spread it through the day, week, month / Strain / Material

Click to expand...

That does sound intense but perfect. I don't know why but I am such a big fan of crazy experiences like that. It probably has something to do with it being so far from the contrast of normal day to day life that attracts me. I'd like to try that out and even if it doesn't seem to be what I am looking for it'll be pretty nice to know that one can control the body to modify tolerance in such a way.

synche said:

In reply to OP,

I don't know anything about up or down regulation of cannabinoid receptors but I do know that when I modified my DBV to accomodate small bowls my use and tolerance decreased fairly dramatically.

Just switching from smoking to vaping with the standard DBV whip I immediately decreased my consumption from about 3.5g/day to about 1.5g/day.

Then, after using an 18mm/14mm gg reducer, paired with a 14mm/14mm m/m gg adapter as the wand my consumption has decreased to .6g/day (5 - 1/8ths in last 29 days). My normal bowls are from about .025g to .033g.

In less than 3 months I went from an eighth a day to an eighth every 6 days and I'm not doing this to save money. I am fortunate to always have free cannabis. At this point I could vape 2 grams/day and make it till trim season, but .6g satisfies me. This will allow me to give a couple ounces away to friends in need. I love to give away weed and will be able to thanks to my DBV.

I attribute my greatly lowered tolerance to feeling more satisfied with less. The clear headed, more euphoric effects of vaping vs smoking naturally and organically led to my lowered usage and tolerance.

Click to expand...

That's great thanks for the information. It proves that one can get their tolerance as low as they can by the simple method of lowering the consumption but not the frequency (to a point). One doesn't even have to get it so low to the point of feeling what Roger D felt you just half to find your sweet spot.



Another side note Roger D this is a bit off topic but while you were on the method of .025 did you notice more pleasure in your day to day life? Up-regulating the cannabinoid receptors should lead to more receptors for your "natural high" molecules to bind (ex: Anandamide (which closely resembles the THC molecule)) to. For instance a better running high or just in general enjoying things more like eating your favorite food or taking a walk.

What I have been doing lately is actually using my heavy hitting vapes in the morning, start of the day, and then at the end of the day and night I've been strictly using my MFLB. I feel better all around....not as groggy in the morning, I feel as tho I get medicated waaaay more, and I'm saving bud! Try it out it's really cool!

persontothe said:

Another side note Roger D this is a bit off topic but while you were on the method of .025 did you notice more pleasure in your day to day life? Up-regulating the cannabinoid receptors should lead to more receptors for your "natural high" molecules to bind (ex: Anandamide (which closely resembles the THC molecule)) to. For instance a better running high or just in general enjoying things more like eating your favorite food or taking a walk.

Click to expand...

Thinking back.. That was a while ago. I may have been enjoying things that I don't enjoy anymore, that could be other factors, but there was maybe something like that yeah. I was a little more numbed tho.

Now that I have a much better tolerance, I can chain bowls even on an empty stomach without any head spinning, tension drop or weakness feelings. Setting up your tolerance is one of the keys to achieve a proper medication. Its also about what you eat. Think quality fats. Fat is a primordial carrier and acts as a biologic lubricant. Get hooked on various oleaginous seeds, pure cocoa paste, free range dairies & meats, omega rich fish... If you stick to that high quality intake you'll feel it.

I think I'm gonna try this... I love having low tolerance so much that I tend to wait several days, or even up to a week between each session... but I haven't ever considered the possibility that using less weed each session might lower my tolerance even more than taking breaks... I always thought of it as the time between highs being the most important factor in lowering tolerance, so I opt for "more weed, less often" to get the maximum potential... but maybe the "less weed, less often" would be even better... Less is more?

What I found to help up-regulation, is this. You wake up, and do a small time of cardio for like 6-10 minutes to get your body going for the day. Make sure you are sweating. I like going fast for 15 seconds, every minutes for six minutes, this allows me to get more of a workout then if I were to just run the same for the whole six minutes.

Then, you you a whole meal that contains protein, fat, and carbs. Then just puff all day, but not gigantic puffs, you want nice small consistent puffs that keep you feeling nice but not knocked out. Then when it is getting close to the evening, you do a resistance training routine, but not a lengthy one, you just want to activate your muscles more then they normally are. I just do 2 sets of 5 reps, but I increase the weight every time I do a new session on a different day for whatever body part I'm working on that day. You then eat a meal containing mostly carbohydrates, with a little fat, and protein to replace the glycogen, and some protein/fat, you lost during your workout.

What this does is allow your body metabolize the cannabis effectively since your are constantly taking in small amounts instead of one big hit all at once, and when you do resistance training, you are training your body to hold on to the substances you used before doing the resistance training very effectively. This will ultimately lead to up-regulation of cannabinoids. When you have too much substances come into your system at once, and the body isn't able to process all of them, down-regulation occurs. The cardio also helps because, it down-regulates your fat storing capabilities, which means less cannabinoids being sucked up by your fat cells, and more going to the parts that are more active, which means more of a high. Make sure you get good sleep, because that is when the body decides if it needs to up or down-regulate.

This technique may seem hard at first, but you will get used to it. It will have you be able to enjoy small amounts, but you can puff all day, and get more blazed then someone who is used to taking big hits because it will keep getting stronger as you inhale throughout your day due to having so many receptors being able to be filled, processed, and holding onto the cannabinoids much longer then usual due to the resistance training.

that's basically what i do, too.

i have a NordicTrack and a Bowflex. i do all my exercise first thing in the morning on a calorie deficit -- 30 mins on the NT, and i agree on the sweat -- i feel like i'm cleaning my body from the inside out, plus elevating the core body temp kills virus and oxygenates all the cells -- very addictive after several weeks. some days the first 6 minutes on the NT are excruciating, but after that it's just smooth striding.

Although i've been using the NT for 30 years, the Bowflex is new for me. i've had this machine for several years and only now making it a regular component of my routine.

See, once i hit 65, i noticed a dramatic drop in my energy level. Rather than pop testosterone pills or some other fucked up pharm, i decided to make my own testosterone by asking my body to make it -- via BF resistance training, doing about 20 min per day. i go 3 days of exercise then one day of rest. after less than a month i am seeing an improvement and really enjoying the results.

the aerobics got my eating right. only whole foods (omnivore, but not much meat), (mostly) no crap (i do like a pastry in the morning with my fruit and coffee). and a small B&J after dinner. lots of nuts (4 to 6 oz).

and small vape sessions all day. The VaporPsi is right by my keyboard. everything fits neatly into its case - 6" x 3" x 2".

and only cotton clothes! tis great to be self-employed.